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FGF18 Antibody (BS-9762R) in IHC (P)
Paraformaldehyde-fixed, paraffin embedded mouse skin; Antigen retrieval by boiling in sodium citrate buffer (pH6) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (normal goat serum) at 37°C for 20min; Antibody incubation with FGF18 Polyclonal Antibody (bs-9762R) at 1:400 overnight at 4°C, followed by conjugated Goat Anti-Rabbit IgG antibody (bs-0295G-FITC) for ... View More
Product Details
BS-9762R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FGF18, amino acids 95-145.
Conjugate
Unconjugated
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS with 50% glycerol, 1% BSA
Contains
0.09% sodium azide
Storage conditions
-20°C
Target Information
FGF18 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-18; Fibroblast growth factor; Fibroblast growth factor 18; zFGF5
Gene Aliases: D130055P09Rik; FGF-18; FGF18; UNQ420/PRO856; ZFGF5
UniProt ID: (Human) O76093, (Mouse) O89101, (Rat) O88182
Entrez Gene ID: (Human) 8817, (Mouse) 14172, (Rat) 29369
Molecular Function:
growth factor
intercellular signal molecule
MAPK cascade
angiogenesis
regulation of endothelial cell proliferation
intramembranous ossification
endochondral ossification
chondrocyte development
signal transduction
cell-cell signaling
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
anatomical structure morphogenesis
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
lung development
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of chondrocyte differentiation
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of ERK1 and ERK2 cascade
regulation of sprouting angiogenesis
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
ossification
nervous system development
cell proliferation
protein tyrosine kinase activity
Ras guanyl-nucleotide exchange factor activity
type 1 fibroblast growth factor receptor binding
type 2 fibroblast growth factor receptor binding
growth factor activity
1-phosphatidylinositol-3-kinase activity
phosphatidylinositol-4,5-bisphosphate 3-kinase activity
receptor binding
fibroblast growth factor receptor binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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