Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
FIGURE: 1 / 2
FGF18 Antibody (PA5-78261) in WB
FGF18 Polyclonal Antibody detects FGF18 protein by western blot analysis. A. 30 µg 293T whole cell lysate/extract. B. 30 µg whole cell lysate/extract of human FGF18-transfected 293T cells.12 % SDS-PAGE. FGF18 Polyclonal Antibody (Product # PA5-78261) dilution: 1:500.
Product Details
PA5-78261
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human FGF18. The exact sequence is proprietary.
Conjugate
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2735778
Product Specific Information
Positive Control: U2OS, human FGF18-transfected 293T
Predicted Reactivity: Mouse (100%), Rat (100%), Chicken (98%), Bovine (100%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
FGF18 is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: FGF; FGF-18; Fibroblast growth factor; Fibroblast growth factor 18; zFGF5
Gene Aliases: FGF-18; FGF18; UNQ420/PRO856; ZFGF5
UniProt ID: (Human) O76093
Entrez Gene ID: (Human) 8817
Molecular Function:
growth factor
intercellular signal molecule
MAPK cascade
angiogenesis
regulation of endothelial cell proliferation
intramembranous ossification
endochondral ossification
chondrocyte development
signal transduction
cell-cell signaling
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
anatomical structure morphogenesis
regulation of phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
lung development
positive regulation of vascular endothelial growth factor receptor signaling pathway
positive regulation of chondrocyte differentiation
phosphatidylinositol-3-phosphate biosynthetic process
positive regulation of MAP kinase activity
positive regulation of GTPase activity
phosphatidylinositol phosphorylation
phosphatidylinositol-mediated signaling
positive regulation of ERK1 and ERK2 cascade
regulation of sprouting angiogenesis
positive regulation of endothelial cell chemotaxis to fibroblast growth factor
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support