OriGene

FGF2 Polyclonal Antibody

View all (40) FGF2 antibodies

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Product Details

TA890058

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein of human FGF2

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; FGF-2; FGF-b; Fibroblast growth factor; Fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; H-FGF-b-147; H-FGF-b-154; HBGF-2; Heparin-binding growth factor 2; M-FGF-b; prostatropin

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Gene Aliases: BFGF; FGF-2; FGF2; FGFB; HBGF-2

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UniProt ID: (Human) P09038, (Rat) P13109

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Entrez Gene ID: (Human) 2247, (Rat) 54250

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Function(s)
protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity fibroblast growth factor receptor binding cytokine activity protein binding growth factor activity heparin binding 1-phosphatidylinositol-3-kinase activity ligand-dependent nuclear receptor transcription coactivator activity chemoattractant activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity growth factor intercellular signal molecule
Process(es)
MAPK cascade activation of MAPK activity branching involved in ureteric bud morphogenesis positive regulation of endothelial cell proliferation cell migration involved in sprouting angiogenesis phosphatidylinositol biosynthetic process chemotaxis signal transduction Ras protein signal transduction nervous system development positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway organ morphogenesis negative regulation of fibroblast migration positive regulation of phospholipase C activity regulation of phosphatidylinositol 3-kinase signaling growth factor dependent regulation of skeletal muscle satellite cell proliferation peptidyl-tyrosine phosphorylation extracellular matrix organization hyaluronan catabolic process inositol phosphate biosynthetic process somatic stem cell population maintenance phosphatidylinositol-3-phosphate biosynthetic process wound healing positive regulation of cell fate specification positive regulation of MAP kinase activity positive regulation of blood vessel endothelial cell migration negative regulation of blood vessel endothelial cell migration positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity regulation of angiogenesis positive regulation of angiogenesis positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling embryonic morphogenesis positive chemotaxis release of sequestered calcium ion into cytosol positive regulation of cell division positive regulation of cardiac muscle cell proliferation negative regulation of cell death chondroblast differentiation negative regulation of wound healing positive regulation of ERK1 and ERK2 cascade positive regulation of sprouting angiogenesis regulation of endothelial cell chemotaxis to fibroblast growth factor positive regulation of endothelial cell chemotaxis to fibroblast growth factor activation of MAPKK activity angiogenesis organ induction positive regulation of protein phosphorylation aging negative regulation of cell proliferation embryo development ending in birth or egg hatching glial cell differentiation positive regulation of endothelial cell migration positive regulation of gene expression substantia nigra development positive regulation of cerebellar granule cell precursor proliferation lung development positive regulation of cell differentiation positive regulation of osteoblast differentiation regulation of retinal cell programmed cell death positive regulation of smooth muscle cell proliferation response to axon injury stem cell development positive regulation of epithelial cell proliferation regulation of cell cycle positive regulation of protein kinase B signaling corticotropin hormone secreting cell differentiation thyroid-stimulating hormone-secreting cell differentiation mammary gland epithelial cell differentiation angiogenesis involved in coronary vascular morphogenesis positive regulation of canonical Wnt signaling pathway
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