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Invitrogen
FGF23 Polyclonal Antibody
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FIGURE: 1 / 1
FGF23 Antibody (PA5-97747) in WB
Western Blot analysis of FGF23 using a FGF23 Polyclonal antibody (Product # PA5-97747) at a concentration of 2 µg/mL. Positive WB detected in Rat heart tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:10,000 dilution. Observed band size: 28 kDa.
Product Details
PA5-97747
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Rat Fibroblast growth factor 23 protein (25-251AA)
Conjugate
Form
Liquid
Concentration
3.0 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The protein encoded by this gene is a member of the fibroblast growth factor family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The product of this gene inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets, an inherited phosphate wasting disorder. Abnormally high level expression of this gene was found in oncogenic hypophosphatemic osteomalacia, a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations in this gene have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FGF; FGF-23; Fibroblast growth factor; Fibroblast growth factor 23
Gene Aliases: Fgf23
UniProt ID: (Rat) Q8VI82
Entrez Gene ID: (Rat) 170583
phosphate-containing compound metabolic process
fibroblast growth factor receptor signaling pathway
regulation of phosphate transport
positive regulation of vitamin D 24-hydroxylase activity
cell differentiation
regulation of bone mineralization
negative regulation of bone mineralization
cellular phosphate ion homeostasis
vitamin D metabolic process
vitamin D catabolic process
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
negative regulation of hormone secretion
phosphate ion homeostasis
positive regulation of ERK1 and ERK2 cascade
positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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