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Invitrogen
FGF4 Polyclonal Antibody
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Product Details
PA5-79256
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence in the middle region of human FGF4 (84-97aa RRLYCNVGIGFHLQ).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.05mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: HELA Cell.
Target Information
Fibroblast growth factor 4 (FGF4) is a member of the fibroblast growth factor (FGF) family that possess broad mitogenic and cell survival activities and play key roles in growth and survival of stem cells during embryogenesis, tissue regeneration, and carcinogenesis. FGF4 was identified by its strong oncogenic transforming activity and is a potent angiogenic factor, expressed in several highly vascularized tumors and also in adult mouse testis, intestine, and brain. Studies on the mouse homolog suggests a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. Furthermore, FGF4 regulates neural progenitor cell proliferation and neuronal differentiation. Recent studies show a growth-promoting role for FGF4 in human embryonic stem cells and a putative feedback inhibition mechanism by a novel FGF4 splice isoform that may serve to promote differentiation at a later stages of development.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF; FGF-4; FGF4si; Fibroblast growth factor; fibroblast growth factor (put.); putative; Fibroblast growth factor 4; HBGF-4; heparin secretory transforming protein 1; Heparin secretory-transforming protein 1; heparin-binding growth factor 1; Heparin-binding growth factor 4; HST; human stomach cancer, transforming factor from FGF-related oncogene; K-fibroblast growth factor; kaposi sarcoma oncogene; oncogene HST; Transforming protein KS3
Gene Aliases: FGF-4; FGF4; Fgfk; HBGF-4; HST; HST-1; Hst1; HSTF-1; HSTF1; K-FGF; KFGF; KS3
UniProt ID: (Human) P08620, (Mouse) P11403
Entrez Gene ID: (Human) 2249, (Rat) 116499, (Mouse) 14175
cartilage condensation
apoptotic process
signal transduction
cell-cell signaling
cell proliferation
positive regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
mesenchymal cell proliferation
regulation of gene expression
positive regulation of gene expression
stem cell population maintenance
neurogenesis
cell differentiation
embryonic limb morphogenesis
regulation of cell migration
somatic stem cell population maintenance
embryonic hindlimb morphogenesis
odontogenesis of dentin-containing tooth
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of transcription from RNA polymerase II promoter
positive regulation of cell division
cranial suture morphogenesis
apoptotic process involved in morphogenesis
chondroblast differentiation
positive regulation of ERK1 and ERK2 cascade
stem cell proliferation
epithelial cell apoptotic process
cellular response to leukemia inhibitory factor
regulation of endothelial cell chemotaxis to fibroblast growth factor
positive regulation of stem cell proliferation
positive regulation of protein phosphorylation
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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