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Invitrogen
FGFR1OP2 Polyclonal Antibody
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FIGURE: 1 / 1
FGFR1OP2 Antibody (PA5-97749) in WB
Western Blot analysis of FGFR1OP2 using a FGFR1OP2 Polyclonal antibody (Product # PA5-97749) at a concentration of 6 µg/mL. Lane 1: Mouse gonadal tissue. Lane 2: Human placenta tissue. A secondary Goat polyclonal antibody to rabbit IgG was applied at a 1:10,000 dilution. Observed band size: 30 kDa.
Product Details
PA5-97749
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human FGFR1 oncogene partner 2 protein (1-172AA)
Conjugate
Form
Liquid
Concentration
3 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
FGFR1OP2, also known as FGFR1 oncogene partner 2, is a gene that plays a crucial role in oncogenesis, particularly in myeloproliferative neoplasms. It is known to interact with the FGFR1 (Fibroblast Growth Factor Receptor 1) through chromosomal translocations that can lead to malignancies, such as the formation of the fusion protein FGFR1OP2-FGFR1 in KG-1a leukemic cells. FGFR1OP2 itself is a gene encoding a protein whose function is not entirely understood, but its association with FGFR1 highlights its potential role in oncogenic pathways. The FGFR1 component of the fusion is a receptor tyrosine kinase involved in various cellular processes like cell proliferation, migration, and differentiation. The disruption of these processes through abnormal expression or structural changes such as fusions can lead to uncontrolled cell growth and malignancies. FGFR1 is also frequently studied as a therapeutic target in cancer, given its importance in cellular signaling and cancer progression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGFR1 oncogene partner 2; FGFR1 oncogene partner 2 homolog; fibroblast growth factor receptor 1 oncogene partner 2; wound inducible transcript 3.0
Gene Aliases: 1500031J01Rik; FGFR1OP2; HSPC123; HSPC123-like; WIT3.0
UniProt ID: (Human) Q9NVK5, (Mouse) Q9CRA9
Entrez Gene ID: (Human) 26127, (Mouse) 67529
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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