This polyclonal antibody raised against 358-704 aa of human FGFR2 can cross react with other members of the FGFR family.
Immunogen sequence: EFPRDKLTL GKPLGEGCFG QVVMAEAVGI DKDKPKEAVT VAVKMLKDDA TEKDLSDLVS EMEMMKMIGK HKNIINLLGA CTQDGPLYVI VEYASKGNLR EYLRARRPPG MEYSYDINRV PEEQMTFKDL VSCTYQLARG MEYLASQKCI HRDLAARNVL VTENNVMKIA DFGLARDINN IDYYKKTTNG RLPVKWMAPE ALFDRVYTHQ SDVWSFGVLM WEIFTLGGSP YPGIPVEELF KLLKEGHRMD KPANCTNELY MMMRDCWHAV PSQRPTFKQL VEDLDRILTL TTNEEYLDLS QPLEQYSPSY PDTRSSCSSG DDSVFSPDPM PYEPCLPQYP HINGSVKT (358-704 aa encoded by BC039243)
FGFR2 is a member of the fibroblast growth factor receptor family. It is a tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a central role in the regulation of cell proliferation, differentiation, migration, apoptosis, and embryonic development. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
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Protein Aliases: bacteria-expressed kinase; BEK fibroblast growth factor receptor; CD332; FGF Receptor 2; FGFR-2; Fibroblast growth factor receptor 2; K-sam; Keratinocyte growth factor receptor; KGFR; protein tyrosine kinase, receptor like 14; Soluble KGFR
Gene Aliases: BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; FGFR2; JWS; K-SAM; KGFR; KSAM; TK14; TK25
UniProt ID: (Human) P21802
Entrez Gene ID: (Human) 2263
Molecular Function: transmembrane signal receptor