A suggested positive control is SK-N-SH cell lysate.
PA5-34574 can be used with blocking peptide PEP-1617.
FGFR3 is a tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. It is required for normal skeleton development and promotes apoptosis in chondrocytes and cancer cell proliferation. FGFR3 protein contains three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. It is alternatively spliced to produce three isoforms that are expressed in brain, kidney and testis. Defects in FGFR3 are associated with several diseases, including achondroplasia and hypochondroplasia. Mutations in FGFR3 are also a cause of some bladder and cervical cancers.
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Protein Aliases: ACH; CD333; CEK2; FGF Receptor 3; FGFR-3; Fibroblast Growth Factor Receptor 3; fibroblast growth factor receptor 3 variant 4; heparin-binding growth factor receptor; HSFGFR3EX; hydroxyaryl-protein kinase; JTK4; tyrosine kinase JTK4
Gene Aliases: ACH; CD333; CEK2; Fgfr-3; FGFR3; Flg-2; FR3; HBGFR; HSFGFR3EX; JTK4; Mfr3; sam3
UniProt ID: (Human) P22607