Search Thermo Fisher Scientific
- Contact Us
- Quick Order
-
Don't have an account ? Create Account
Search Thermo Fisher Scientific
FIGURE: 1 / 2
In direct ELISAs, approximately 15% cross-reactivity with recombinant human (rh) FGF R4 is observed, 5% cross-reactivity with rhFGF R1 alpha (IIIb), rhFGF R1 alpha (IIIc), and rhFGF R1 beta (IIIb) is observed, and less than 1% cross-reactivity with recombinant mouse (rm) FGF R2 alpha (IIIb), rmFGF R2 beta (IIIb), rmFGF R2 beta (IIIc), rmFGF R3 alpha (IIIb), rmFGF R3 alpha (IIIc), rmFGF R5, and rmFGF R5 beta is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family is known to regulate a host of cellular functions including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury. The FGFR family has also been implicated in a number of diseases including cancer, rheumatoid arthritis, and diabetic retinopathy. FGFR4 is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. FGFR4 plays a role in postnatal lung development and may be involved in the development of skeletal muscle cell lineages.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD334; CTLA-2-beta protein; FGF Receptor 4; FGFR-4; Fibroblast growth factor receptor 4; fibroblast growth factor receptor 4 16 minus form; MGC20292; Protein-tyrosine kinase receptor MPK-11
Gene Aliases: Fgfr-4; Fgfr4; Mpk-11
UniProt ID: (Mouse) Q03142
Entrez Gene ID: (Mouse) 14186
Molecular Function: transmembrane signal receptor
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn moreGet expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support