Peptide sequence: RPDITWMKDD QALTRPEAAE PRKKKWTLSL KNLRPEDSGK YTCRVSNRAG
Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.
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Protein Aliases: FGF homologous factor receptor; FGF receptor-like protein 1; FGFR-5; FGFR-like protein; Fibroblast growth factor receptor 5; Fibroblast growth factor receptor-like 1
Gene Aliases: FGFR5; FGFRL1; FHFR; UNQ480/PRO943
UniProt ID: (Human) Q8N441
Entrez Gene ID: (Human) 53834
Molecular Function: tyrosine protein kinase receptor