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Product Details
PA5-45228
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the middle region of human FGFRL1
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2606700
Product Specific Information
Peptide sequence: RPDITWMKDD QALTRPEAAE PRKKKWTLSL KNLRPEDSGK YTCRVSNRAG
Target Information
Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FGF homologous factor receptor; FGF receptor-like protein 1; FGFR-5; FGFR-like protein; Fibroblast growth factor receptor 5; Fibroblast growth factor receptor-like 1
Gene Aliases: FGFR5; FGFRL1; FHFR; UNQ480/PRO943
UniProt ID: (Human) Q8N441
Entrez Gene ID: (Human) 53834
Molecular Function:
tyrosine protein kinase receptor
skeletal system development
heart valve morphogenesis
negative regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
substrate adhesion-dependent cell spreading
protein homooligomerization
protein heterooligomerization
ventricular septum morphogenesis
diaphragm development
cell-cell adhesion via plasma-membrane adhesion molecules
Performance Guarantee
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