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Invitrogen
FGFR5 Polyclonal Antibody
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Product Details
PA5-77276
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 160-210 of Human FGFR5.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuro-ectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. A total of six members of the FGF receptor family have been identified and cloned. These include the Flg receptor or FGFR-1, the BEK receptor or FGFR-2, FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. However, FGFR-5 lacks the cytoplasmic kinase domain. FGFR-5 is expressed in a broad range of tissues, including kidney, brain and lung, but it is preferentially expressed in pancreas, where it may play a role in the regulation of some pancreatic function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-L-iduronidase; FGF homologous factor receptor; FGF receptor-like protein 1; FGFR-5; FGFR-like protein; Fibroblast growth factor receptor 5; Fibroblast growth factor receptor-like 1; fibroblast growth factor receptor-like protein
Gene Aliases: FGFR5; FGFR5beta; FGFR5gamma; FGFRL1; FHFR; UNQ480/PRO943
UniProt ID: (Human) Q8N441, (Mouse) Q91V87, (Rat) Q7TQM3
Entrez Gene ID: (Human) 53834, (Mouse) 116701, (Rat) 360903
skeletal system development
heart valve morphogenesis
negative regulation of cell proliferation
fibroblast growth factor receptor signaling pathway
substrate adhesion-dependent cell spreading
protein homooligomerization
protein heterooligomerization
ventricular septum morphogenesis
diaphragm development
cell-cell adhesion via plasma-membrane adhesion molecules
cell surface receptor signaling pathway
peptidyl-tyrosine phosphorylation
negative regulation of fibroblast growth factor receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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