Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene.
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Protein Aliases: fibrinogen-like 1; Fibrinogen-like protein 1; Fibrinogen-related protein 1; fibronigen-like protein 1; Hepassocin; hepatocellular carcinoma-related sequence; Hepatocyte-derived fibrinogen-related protein 1; HFREP-1; HP-041; HPS; LFIRE-1; Liver fibrinogen-related protein 1; Liver fibrinogen-related protein-1; MFIRE-1; Mfrep-1; MGC12455; OTTHUMP00000122468
Gene Aliases: FGL1; Frep1; HFREP1; HP-041; LFIRE-1; LFIRE1; Mfire1
Molecular Function: signaling molecule