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Fabgennix
FGR Polyclonal Antibody
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Product Details
FGR-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 443-450 on human Fgr protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 0.5% BSA, 30% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
FGR is a SRC-related kinase present in hematopoietic cells. FGR signals within multiple pathways including within the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: c-fgr protooncogene; c-src-2 proto-oncogene; EC 2.7.10.2; feline Gardner-Rasheed sarcoma viral oncogene; feline Gardner-Rasheed sarcoma viral oncogene homolog; FGR protein; FLJ43153; Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; OTTHUMP00000003603; OTTHUMP00000003604; p55-c-fgr protein; p55-Fgr; p58-Fgr; p58c-Fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; Tyrosine-protein kinase Fgr; unnamed protein product; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
Gene Aliases: c-fgr; c-src2; FGR; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; SRC2
UniProt ID: (Human) P09769, (Mouse) P14234, (Rat) Q6P6U0
Entrez Gene ID: (Human) 2268, (Mouse) 14191, (Rat) 79113
nucleotide binding
phosphotyrosine binding
protein kinase activity
protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor binding
protein binding
ATP binding
kinase activity
transferase activity
protein kinase binding
immunoglobulin receptor binding
Fc-gamma receptor I complex binding
transferase activity, transferring phosphorus-containing groups
immune system process
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
integrin-mediated signaling pathway
regulation of cell shape
positive regulation of phosphatidylinositol 3-kinase signaling
phosphorylation
peptidyl-tyrosine phosphorylation
cell differentiation
positive regulation of cell migration
regulation of actin cytoskeleton organization
peptidyl-tyrosine autophosphorylation
regulation of cell proliferation
positive regulation of mast cell degranulation
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of innate immune response
regulation of protein kinase activity
protein autophosphorylation
positive regulation of cytokine secretion
regulation of phagocytosis
defense response to Gram-positive bacterium
cellular response to peptide hormone stimulus
positive regulation of cytokine production
immune response-regulating cell surface receptor signaling pathway
negative regulation of inflammatory response to antigenic stimulus
response to virus
bone mineralization
negative regulation of natural killer cell activation
Fc-gamma receptor signaling pathway involved in phagocytosis
skeletal system morphogenesis
positive regulation of protein kinase B signaling
biological_process
cell migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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