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|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 268 of Human FGR|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 10% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28624 targets FGR in IF, IHC (P), and WB applications and shows reactivity with Human samples.
The PA5-28624 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 268 of Human FGR.
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
c-fgr; c-fgr protooncogene; c-src-2 proto-oncogene; c-src2; feline Gardner-Rasheed sarcoma viral oncogene homolog; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; p55-c-fgr protein; p55c-fgr; p58c-fgr; proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; SRC2; tyrosine-protein kinase Fgr; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
c-fgr; c-src2; FGR; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; SRC2