FIGURE: 1 / 1
Positive Samples: HL-60, U-937, Raji; Cellular Location: Cell membrane, Cell projection, Cytoplasm, Cytoplasmic side, Lipid-anchor, Mitochondrion inner membrane, Mitochondrion intermembrane space, Peripheral membrane protein, cytoskeleton, cytosol, ruffle membrane
FGR is a SRC-related kinase present in hematopoietic cells. FGR signals within multiple pathways including within the integrin pathway and downstream of chemokine and cytokine receptors. This protein contains N-terminal sites for myristylation and palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. It localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this protein.
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Protein Aliases: c-fgr protooncogene; c-src-2 proto-oncogene; EC 126.96.36.199; feline Gardner-Rasheed sarcoma viral oncogene homolog; FGR protein; FLJ43153; Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog; MGC75096; OTTHUMP00000003603; OTTHUMP00000003604; p55-c-fgr protein; p55-Fgr; p58-Fgr; p58c-Fgr; Proto-oncogene c-Fgr; proto-oncogene tyrosine-protein kinase FGR; Tyrosine-protein kinase Fgr; v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog
Gene Aliases: c-fgr; c-src2; FGR; p55-Fgr; p55c-fgr; p58-Fgr; p58c-fgr; SRC2
Molecular Function: scaffold/adaptor protein