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Proteintech
FIGLA Polyclonal Antibody
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Product Details
24845-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FIGLA fusion protein Ag20392
Conjugate
Form
Liquid
Concentration
800 µg/mL
Amount
120 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Sequence of this protein is as follows: MDPAPGVLDP RAAPPALLGT PQAEVLEDVL REQFGPLPQL AAVCRLKRLP SGGYSSTENL QLVLERRRVA NAKERERIKN LNRGFARLKA LVPFLPQSRK PSKVDILKGA TEYIQVLSDL LEGAKDSKKQ DPDEQSYSNN SSESHTSSAR QLSRNITQHI SCAFGLKNEE EGPWADGGSG EPAHACRHSV MSTTEIISPT RSLDRFPEVE LLSHRLPQV
Target Information
Germline specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the E-box (5'-CANNTG-3') of the ZPs (ZP1, ZP2, ZP3) promoters.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bHLH transcription factor; bHLHc8; Class C basic helix-loop-helix protein 8; Factor in the germline alpha; FIG alpha; FIGalpha; folliculogenesis specific basic helix-loop-helix; Folliculogenesis-specific basic helix-loop-helix protein; Transcription factor FIGa
Gene Aliases: BHLHC8; FIGALPHA; FIGLA; POF6; RGD1564754
UniProt ID: (Human) Q6QHK4, (Mouse) O55208
Entrez Gene ID: (Human) 344018, (Mouse) 26910, (Rat) 500239
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein binding
bHLH transcription factor binding
protein dimerization activity
E-box binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor binding
sequence-specific DNA binding
basic helix-loop-helix transcription factor
regulation of transcription from RNA polymerase II promoter
cell differentiation
developmental process
positive regulation of transcription from RNA polymerase II promoter
oogenesis
oocyte development
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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