FIP1L1 is a component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. It binds to U-rich RNA sequence elements surrounding the poly(A) site. FIP1L1 may act to tether poly(A) polymerase to the CPSF complex.
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Protein Aliases: DKFZp586K0717; Factor interacting with PAP; FIP1 like 1; FIP1-like 1 protein; FIP1L1 cleavage and polyadenylation specific factor subunit; FLJ33619; hFip1; Pre-mRNA 3'-end-processing factor FIP1; Rearranged in hypereosinophilia
Gene Aliases: 1300019H17Rik; FIP1; FIP1L1; hFip1; RHE; Rje