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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 2 and 224 of Human FKBP25|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:500-1:3000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA5-28275 targets FKBP25 in WB applications and shows reactivity with Human and mouse samples.
The PA5-28275 immunogen is recombinant fragment corresponding to a region within amino acids 2 and 224 of Human FKBP25.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
25 kDa FK506-binding protein; 25 kDa FKBP; FK506 binding protein 3, 25kDa; FK506-binding protein 25; FK506-binding protein 25, T-cell; FK506-binding protein 3 (25kD); FKBP-25; FKBP-3; FKBP25; immunophilin FKBP25; peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; rapamycin binding protein; rapamycin-selective 25 kDa immunophilin; rotamase; T-cell
25kDa; FKBP-25; FKBP-3; FKBP25; FKBP3; PPIase