Immunogen sequence: LPKKDIIKFL QEHGSDSFLA EHKLLGNIKN VAKTANKDHL VTAYNHLFET KRFKGTESIS KVSEQVKNVK LNEDKPKETK SEETLDEGPP KYTKSVLKKG DKTNFPKKGD VVHCWYTGTL QDGT
Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 94%.
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 25 kDa FK506-binding protein; 25 kDa FKBP; FK506 binding protein 3, 25kDa; FK506-binding protein 25, T-cell; FK506-binding protein 3; FK506-binding protein 3 (25kD); FKBP-25; FKBP-3; Immunophilin FKBP25; Peptidyl-prolyl cis-trans isomerase FKBP3; PPIase FKBP3; rapamycin binding protein; Rapamycin-selective 25 kDa immunophilin; Rotamase
Gene Aliases: 25kDa; FKBP-25; FKBP-3; FKBP25; FKBP3; PPIase