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Proteintech
FKBP52 Polyclonal Antibody
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Product Details
10655-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Chicken,
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FKBP52 Fusion Protein Ag1019 (1-286 aa encoded by BC007924)
Conjugate
Form
Liquid
Concentration
0.33 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTAEEMKAT ESGAQSAPLP MEGVDISPKQ DEGVLKVIKR EGTGTEMPMI GDRVFVHYTG WLLDGTKFDS SLDRKDKFSF DLGKGEVIKA WDIAIATMKV GEVCHITCKP EYAYGSAGSP PKIPPNATLV FEVELFEFKG EDLTEEEDGG IIRRIQTRGE GYAKPNEGAI VEVALEGYYK DKLFDQRELR FEIGEGENLD LPYGLERAIQ RMEKGEHSIV YLKPSYAFGS VGKEKFQIPP NAELKYELHL KSFEKAKESW EMNSEEKLEQ STIVKERGTV YFKEGKY (1-286 aa encoded by BC007924)
Target Information
FKBP4, encoding FK506-binding protein 4, is part of the immunophilin family and plays roles in cellular processes like protein folding and trafficking. The FKBP4 gene is located on chromosome 12, where it encodes a protein involved in modulating the androgen receptor signaling pathway and has been implicated in various cancers, including non-small-cell lung cancer (NSCLC) and hepatocellular carcinoma (HCC). Structural variants of FKBP4 found through exome sequencing have shown potential deleterious effects on protein function. This gene is associated with cell proliferation, apoptosis, migration, and invasion in cancer cells. FKBP4 also influences metabolic processes, such as glycolysis, thereby contributing to cancer cell survival and growth. Importantly, FKBP4 has a role in disorders of sexual development due to its regulatory interaction with hormone signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 51 kDa FK506-binding protein; 52 kDa FK506-binding protein; 52 kDa FKBP; 59 kDa immunophilin; FK506 binding protein 4, 59kDa; FK506-binding protein 4; FK506-binding protein 4 (59kD); FKBP-4; FKBP51; FKBP59; HBI; HSP binding immunophilin; HSP-binding immunophilin; Immunophilin FKBP52; p59; Peptidyl-prolyl cis-trans isomerase FKBP4; peptidylprolyl cis-trans isomerase; PPIase FKBP4; Rotamase; T-cell FK506-binding protein, 59kD
Gene Aliases: 59kDa; AL022792; AW208983; FKBP-4; FKBP-52; FKBP4; FKBP51; FKBP52; FKBP59; FKPB52; HBI; Hsp56; p52; p59; PPIase
UniProt ID: (Human) Q02790, (Mouse) P30416
Entrez Gene ID: (Human) 2288, (Mouse) 14228
peptidyl-prolyl cis-trans isomerase activity
protein binding
ATP binding
GTP binding
FK506 binding
protein binding, bridging
heat shock protein binding
copper-dependent protein binding
glucocorticoid receptor binding
poly(A) RNA binding
tau protein binding
phosphoprotein binding
isomerase activity
chaperone
protein peptidyl-prolyl isomerization
protein folding
steroid hormone receptor complex assembly
copper ion transport
embryo implantation
negative regulation of neuron projection development
androgen receptor signaling pathway
prostate gland development
negative regulation of microtubule polymerization or depolymerization
negative regulation of microtubule polymerization
protein complex localization
male sex differentiation
chaperone-mediated protein folding
regulation of cellular response to heat
reproductive structure development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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