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Invitrogen
FLASH Polyclonal Antibody
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Product Details
PA1-4168
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues W(1909) T R N D D R E I L L E(1920) of mouse FLASH.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA1-4168 detects the FLASH protein in mouse samples.
PA1-4168 has been successfully used in Western blot procedures. By Western blot this antibody detects a ~212 kDa protein representing FLASH in NIH3T3 cells.
The PA1-4168 immunogen is a synthetic peptide corresponding to residues W(1909) T R N D D R E I L L E(1920) of mouse FLASH.
Target Information
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CASP8-associated protein 2; casp8ap2; FLICE-associated huge protein; FLJ11208; RP11-63K6.3
Gene Aliases: AA387232; Casp8ap2; D4Ertd659e; FLASH; mKIAA1315
UniProt ID: (Mouse) B1AX74
Entrez Gene ID: (Mouse) 26885
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
cell cycle
extrinsic apoptotic signaling pathway via death domain receptors
Fas signaling pathway
negative regulation of nucleic acid-templated transcription
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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