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Proteintech
FLCN Polyclonal Antibody
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Product Details
11236-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FLCN Fusion Protein Ag1746 (1-342 aa encoded by BC015687)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody can recognize all the 3 isoforms of FLCN (38-45 kDa,64 kDa,20-26 kDa).
Immunogen sequence: MNAIVALCH FCELHGPRTL FCTEVLHAPL PQGDGNEDSP GQGEQAEEEE GGIQMNSRMR AHSPAEGASV ESSSPGPKKS DMCEGCRSLA AGHPGYISHD KETSIKYVSH QHPSHPQLFS IVRQACVRSL SCEVCPGREG PIFFGDEQHG FVFSHTFFIK DSLARGFQRW YSIITIMMDR IYLINSWPFL LGKVRGIIDE LQGKALKVFE AEQFGCPQRA QRMNTAFTPF LHQRNGNAAR SLTSLTSDDN LWACLHTSFA WLLKACGSRL TEKLLEGAPT EDTLVQMEKL AGEAGVLLPG PWPGWPWGGT SCLLSWQESL REGNAALNQP RTSLREAHPP ISV (1-342 aa encoded by BC015687)
Target Information
This gene encodes a mitochondrial protein that is characterized by a poly-proline rich region. A chicken homolog of this protein promotes mitochondrial fission and the mouse homolog protects cells from oxidative stress. A related pseudogene of this gene is found on chromosome X.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BHD skin lesion fibrofolliculoma protein; Birt-Hogg-Dube syndrome protein; Birt-Hogg-Dube syndrome protein homolog; Folliculin
Gene Aliases: AU014660; B430214A04Rik; BHD; FLCL; FLCN
UniProt ID: (Human) Q8NFG4, (Mouse) Q8QZS3, (Rat) Q76JQ2
Entrez Gene ID: (Human) 201163, (Mouse) 216805, (Rat) 303185
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
regulation of protein phosphorylation
positive regulation of protein phosphorylation
cell-cell junction assembly
positive regulation of autophagy
negative regulation of gene expression
negative regulation of mitochondrion organization
hemopoiesis
negative regulation of cell growth
negative regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
TOR signaling
regulation of TOR signaling
negative regulation of TOR signaling
positive regulation of TOR signaling
regulation of cytokinesis
negative regulation of Rho protein signal transduction
regulation of histone acetylation
positive regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of cell adhesion
positive regulation of transcription from RNA polymerase II promoter
negative regulation of protein kinase B signaling
negative regulation of ERK1 and ERK2 cascade
negative regulation of protein localization to nucleus
negative regulation of cell proliferation involved in kidney development
negative regulation of energy homeostasis
regulation of pro-B cell differentiation
negative regulation of ATP biosynthetic process
negative regulation of angiogenesis
negative regulation of transcription, DNA-templated
negative regulation of cellular respiration
negative regulation of mitochondrial DNA metabolic process
negative regulation of muscle tissue development
negative regulation of post-translational protein modification
positive regulation of intrinsic apoptotic signaling pathway
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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