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Product Details
A305-861A
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A region between residue 100 and 150 of human Filaggrin-2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7.0 to 8.0
Contains
0.09% sodium azide
Storage conditions
4° C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The FLG2 protein is upregulated by calcium, proteolyzed by calpain 1, and is involved in epithelial homeostasis. FLG2 is also required for proper cornification in skin, with defects in this gene being associated with skin diseases. This protein also has a function in skin barrier protection. In fact, in addition to providing a physical barrier, C-terminal fragments of this protein display antimicrobial activity against P. aeruginosa.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Filaggrin-2; FLG-2; Ifapsoriasin; intermediate filament-associated and psoriasis susceptibility protein; Intermediate filament-associated and psoriasis-susceptibility protein
Gene Aliases: FLG2; IFPS
UniProt ID: (Human) Q5D862
Entrez Gene ID: (Human) 388698
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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