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Proteintech
FLI1 Polyclonal Antibody
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Product Details
11347-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FLI1 Fusion Protein Ag1899 (103-452 aa encoded by BC010115)
Conjugate
Form
Liquid
Concentration
0.53 mg/mL
Amount
79.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: NSYMDEKNG PPPPNMTTNE RRVIVPADPT LWTQEHVRQW LEWAIKEYSL MEIDTSFFQN MDGKELCKMN KEDFLRATTL YNTEVLLSHL SYLRESSLLA YNTTSHTDQS SRLSVKEDPS YDSVRRGAWG NNMNSGLNKS PPLGGAQTIS KNTEQRPQPD PYQILGPTSS RLANPGSGQI QLWQFLLELL SDSANASCIT WEGTNGEFKM TDPDEVARRW GERKSKPNMN YDKLSRALRY YYDKNIMTKV HGKRYAYKFD FHGIAQALQP HPTESSMYKY PSDISYMPSY HAHQQKVNFV PPHPSSMPVT SSSFFGAASQ YWTSPTGGIY PNPNVPRHPN THVPSHLGSY Y (103-452 aa encoded by BC010115)
Target Information
The FLI1 (Friend Leukemia Integration 1) gene is located on chromosome 11q24.3 and belongs to the ETS (E26 transformation-specific) family of transcription factors. Structurally, FLI1 contains an ETS domain responsible for DNA binding and a pointed domain which facilitates protein-protein interactions. Functionally, it plays a critical role in the regulation of embryonic and hematopoietic development. It is also implicated in the pathogenesis of diseases such as Ewing's sarcoma, wherein a chromosomal translocation t(11;22)(q24;q12) forms the EWS-FLI1 fusion gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: alternate; ETS transcription factor; Ewing sarcoma breakpoint region 2; Friend leukemia integration 1; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; Retroviral integration site protein Fli-1; similar to FLI-1; Transcription factor ERGB; unnamed protein product
Gene Aliases: BDPLT21; EWSR2; FLI-1; FLI1; SIC-1; Sic1
UniProt ID: (Human) Q01543, (Mouse) P26323
Entrez Gene ID: (Human) 2313, (Mouse) 14247
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
winged helix/forkhead transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
hemostasis
blood circulation
organ morphogenesis
cell differentiation
megakaryocyte development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
transcription from RNA polymerase II promoter
cellular process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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