Search
Huabio
FLI1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 5
FLI1 Antibody (HA500149) in IHC (P)
Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-FLI1 antibody. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (HA500149, 1:400) for 30 minutes at room temperature. Th... View More
Product Details
HA500149
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein within human FLI1 aa 1-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The FLI1 (Friend Leukemia Integration 1) gene is located on chromosome 11q24.3 and belongs to the ETS (E26 transformation-specific) family of transcription factors. Structurally, FLI1 contains an ETS domain responsible for DNA binding and a pointed domain which facilitates protein-protein interactions. Functionally, it plays a critical role in the regulation of embryonic and hematopoietic development. It is also implicated in the pathogenesis of diseases such as Ewing's sarcoma, wherein a chromosomal translocation t(11;22)(q24;q12) forms the EWS-FLI1 fusion gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: alternate; ETS transcription factor; Ewing sarcoma breakpoint region 2; Friend leukemia integration 1; Friend leukemia integration 1 transcription factor; Friend leukemia virus integration 1; Proto-oncogene Fli-1; Retroviral integration site protein Fli-1; similar to FLI-1; Transcription factor ERGB; unnamed protein product
Gene Aliases: BDPLT21; EWSR2; FLI-1; FLI1; SIC-1; Sic1
UniProt ID: (Human) Q01543, (Mouse) P26323
Entrez Gene ID: (Human) 2313, (Rat) 315532, (Mouse) 14247
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
winged helix/forkhead transcription factor
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
hemostasis
blood circulation
organ morphogenesis
cell differentiation
megakaryocyte development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription, DNA-templated
cellular process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support