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|Tested species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A peptide corresponding to amino acids 449 to 465 of mouse FLIPL/CASHa.|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Immunocytochemistry (ICC)||5 µg/ml|
|Western Blot (WB)||0.5 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
In Western blot applications, this antibody detects a band at ~55kDa. A suggested positive control is NIH-3T3 cell lysate.
PA5-19881 can be used with blocking peptide PEP-0013.
Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED-3 protease family.Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH, CLARP and MRIT. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors CD95, DR3, TRAIL-R and TNFR1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
2310024N18Rik, A430105C05Rik, CLARP, Cash, Casper, ENSMUSG00000072980, FLAME, FLAME-1, Flip, Gm9845, I-FLICE, MRIT, c-Flip; CASP8 and FADD-like apoptosis regulator; caspase homolog; caspase-eight-related protein; caspase-like apoptosis regulatory protein; cellular FLICE-like inhibitory protein; FADD-like antiapoptotic molecule 1; inhibitor of FLICE; MACH-related inducer of toxicity; usurpin
2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; Cflar; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip; Gm9845; I-FLICE; MRIT