The antibody is specific to FLNB. It can recognize isoforms 1,2,3,6, and 7 of FLNB. It has no cross reaction to FLNA and FLNC.
FOXK1 is expressed in these cells and regulates cell cycle progression through an interaction with its downstream target the cyclin-dependent kinase inhibitor p21 (CIP). Loss of FOXK1 in mice results in growth retardation and a severe impairment in skeletal muscle regeneration following injury. FOXK1 also shows expression in immature tissues of brain, eye, heart, lung and thymus. It also is predominantly expressed in many malignant tissues, such as tumors of the brain, colon and lymph node.
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Protein Aliases: ABP-278; ABP-280 homolog; ABP-280-like protein; actin binding protein 278; Actin-binding-like protein; Beta-filamin; Fh1; filamin B, beta; Filamin homolog 1; filamin, beta; Filamin-3; Filamin-B; FilaminB; FLN-B; Larsen syndrome 1 (autosomal dominant); Thyroid autoantigen; Truncated ABP; Truncated actin-binding protein
Gene Aliases: ABP-278; ABP-280; AL024016; AOI; FH1; FLN-B; FLN1L; FLN3; FLNB; LRS1; SCT; TABP; TAP