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Invitrogen
FLRG Polyclonal Antibody
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FIGURE: 1 / 1
FLRG Antibody (PA5-87771) in WB
Western blot analysis of FLRG in extracts of various cell lines. Samples were incubated with FLRG Polyclonal antibody (Product # PA5-87771) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.
Product Details
PA5-87771
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 27-263 of human FSTL3 (NP_0058511)
Conjugate
Form
Liquid
Concentration
2.36 mg/mL
Amount
236 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MGSGNPAPGG VCWLQQGQEA TCSLVLQTDV TRAECCASGN IDTAWSNLTH PGNKINLLGF LGLVHCLPCK DSCDGVECGP GKACRMLGGR PRCECAPDCS GLPARLQVCG SDGATYRDEC ELRAARCRGH PDLSVMYRGR CRKSCEHVVC PRPQSCVVDQ TGSAHCVVCR AAPCPVPSSP GQELCGNNNV TYISSCHMRQ ATCFLGRSIG VRHAGSCAGT PEEPPGGESA EEEENFV; Positive Samples: HeLa, DU145, MCF-7, SKOV3, Mouse lung, Mouse kidney, Rat lung; Cellular Location: Nucleus
Target Information
Follistatin-like 3 (FSTL3) is a gene located on chromosome 19p13.3 and encodes a secreted glycoprotein that belongs to the follistatin-related protein family. FSTL3 functions as an antagonist to members of the transforming growth factor-beta (TGF-β) superfamily, particularly inhibiting activin and myostatin signaling. This inhibitory action is crucial for regulating muscle growth, fertility, and inflammation. FSTL3 is expressed in various tissues, including the placenta, gonads, and skeletal muscle, where it modulates physiological processes by binding to and neutralizing the activities of its target ligands. Dysregulation of FSTL3 has been implicated in conditions such as muscle wasting, metabolic syndrome, and reproductive disorders, reflecting its role in maintaining tissue homeostasis and function. Research into FSTL3 focuses on its potential therapeutic applications in diseases involving TGF-β pathway dysregulation, offering insights into strategies for modulating growth factor activities in clinical settings.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLRGFSRP; follistatin-like 3 (secreted glycoprotein); Follistatin-like protein 3; Follistatin-related gene protein; Follistatin-related protein 3; unnamed protein product
Gene Aliases: E030038F23Rik; FLRG; FSRP; FSTL3; UNQ674/PRO1308
UniProt ID: (Human) O95633, (Mouse) Q9EQC7, (Rat) Q99PW7
Entrez Gene ID: (Human) 10272, (Mouse) 83554, (Rat) 114031
ossification
hematopoietic progenitor cell differentiation
regulation of transcription from RNA polymerase II promoter
positive regulation of cell-cell adhesion
cell differentiation
regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
negative regulation of activin receptor signaling pathway
negative regulation of osteoclast differentiation
positive regulation of transcription from RNA polymerase II promoter
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
transcription, DNA-templated
regulation of transcription, DNA-templated
kidney development
spermatogenesis
male gonad development
lung development
adrenal gland development
cellular response to metal ion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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