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Invitrogen
FLT3 Polyclonal Antibody
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Product Details
PA5-34448
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
An 18 amino acid synthetic peptide near the center of human FLT3
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is NIH-3T3 cell lysate.
PA5-34448 can be used with blocking peptide PEP-1490.
Target Information
FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD135; CD135 antigen; Fetal liver kinase 2; Fetal liver kinase-2; FL cytokine receptor; FLK-2; FLT-3; fms related tyrosine kinase 3; Fms-like tyrosine kinase 3; growth factor receptor tyrosine kinase type III; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; Stem cell tyrosine kinase 1; STK-1; tyrosine-protein kinase FLT3; Tyrosine-protein kinase receptor flk-2
Gene Aliases: B230315G04; CD135; FLK-2; FLK2; Flt-3; FLT3; Ly72; STK1; wmfl
UniProt ID: (Human) P36888, (Mouse) Q00342
Entrez Gene ID: (Human) 2322, (Mouse) 14255
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane signaling receptor activity
cytokine receptor activity
vascular endothelial growth factor-activated receptor activity
protein binding
ATP binding
kinase activity
transferase activity
growth factor binding
glucocorticoid receptor binding
macromolecular complex binding
phosphatidylinositol 3-kinase activator activity
transferase activity, transferring phosphorus-containing groups
ubiquitin protein ligase binding
protein complex binding
phosphatidylinositol 3-kinase binding
transmembrane signal receptor
leukocyte homeostasis
myeloid progenitor cell differentiation
pro-B cell differentiation
cell surface receptor signaling pathway
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
positive regulation of macromolecule metabolic process
cell migration
peptidyl-tyrosine phosphorylation
cytokine-mediated signaling pathway
hemopoiesis
B cell differentiation
common myeloid progenitor cell proliferation
vascular endothelial growth factor signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
regulation of apoptotic process
positive regulation of MAP kinase activity
positive regulation of MAPK cascade
lymphocyte proliferation
protein autophosphorylation
positive regulation of protein kinase B signaling
cellular response to cytokine stimulus
cellular response to glucocorticoid stimulus
dendritic cell differentiation
liver regeneration
positive regulation of protein phosphorylation
lymphoid progenitor cell differentiation
pro-T cell differentiation
protein phosphorylation
negative regulation of cell proliferation
phosphorylation
lymphocyte differentiation
cell differentiation
negative regulation of B cell differentiation
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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