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Proteintech
FMN2 Polyclonal Antibody
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Product Details
11259-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FMN2 Fusion Protein Ag1774 (1509-1722 aa encoded by BC014364)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: GQADGFGLD ILPKLKDVKS SDNSRSLLSY IVSYYLRNFD EDAGKEQCLF PLPEPQDLFQ ASQMKFEDFQ KDLRKLKKDL KACEVEAGKV YQVSSKEHMQ PFKENMEQFI IQAKIDQEAE ENSLTETHKC FLETTAYFFM KPKLGEKEVS PNAFFSIWHE FSSDFKDFWK KENKLLLQER VKEAEEVCRQ KKGKSLYKIK PRHDSGIKAK ISMKT (1509-1722 aa encoded by BC014364 )
Target Information
FMN2, a novel formin homology protein of the cappuccino subfamily, is highly conserved between evolutionarily diverse vertebrates. FMN2 bears a high degree of similarity to formin-1 which is the founding member of formin homology proteins. FMN2 plays a crucial role in maintenance of the meiotic spindle. The protein is widely expressed in human fetal brain, adult whole brain, hypothalamus, retina, pancreatic islet and germinal-center B cells. Pathological role of the protein is identified in various tumors like parathyloid tumor, glioblastoma, retinoblastoma and chondrosarcoma. FMN2 mutations are often a cause of unexplained infertility in women. The gene encoding for human FMN2 is localized in the chromosomal region 1q43.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Formin-2; RP11-90L13.1
Gene Aliases: AU024104; FMN2
UniProt ID: (Human) Q9NZ56, (Mouse) Q9JL04
Entrez Gene ID: (Human) 56776, (Mouse) 54418
transport
cellular response to DNA damage stimulus
multicellular organism development
protein transport
vesicle-mediated transport
meiotic chromosome movement towards spindle pole
polar body extrusion after meiotic divisions
negative regulation of protein catabolic process
negative regulation of apoptotic process
actin nucleation
intracellular transport
oogenesis
actin filament bundle assembly
establishment of meiotic spindle localization
homologous chromosome movement towards spindle pole involved in homologous chromosome segregation
formin-nucleated actin cable assembly
cellular response to hypoxia
intracellular signal transduction
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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