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Immunogen sequence: GQADGFGLD ILPKLKDVKS SDNSRSLLSY IVSYYLRNFD EDAGKEQCLF PLPEPQDLFQ ASQMKFEDFQ KDLRKLKKDL KACEVEAGKV YQVSSKEHMQ PFKENMEQFI IQAKIDQEAE ENSLTETHKC FLETTAYFFM KPKLGEKEVS PNAFFSIWHE FSSDFKDFWK KENKLLLQER VKEAEEVCRQ KKGKSLYKIK PRHDSGIKAK ISMKT (1509-1722 aa encoded by BC014364 )
FMN2, a novel formin homology protein of the cappuccino subfamily, is highly conserved between evolutionarily diverse vertebrates. FMN2 bears a high degree of similarity to formin-1 which is the founding member of formin homology proteins. FMN2 plays a crucial role in maintenance of the meiotic spindle. The protein is widely expressed in human fetal brain, adult whole brain, hypothalamus, retina, pancreatic islet and germinal-center B cells. Pathological role of the protein is identified in various tumors like parathyloid tumor, glioblastoma, retinoblastoma and chondrosarcoma. FMN2 mutations are often a cause of unexplained infertility in women. The gene encoding for human FMN2 is localized in the chromosomal region 1q43.
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Protein Aliases: Formin-2; RP11-90L13.1
Gene Aliases: AU024104; FMN2