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Invitrogen
FMN2 Polyclonal Antibody
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FIGURE: 1 / 2
FMN2 Antibody (PA5-23251) in IHC (P)
Immunohistochemical analysis of FMN2 in Tissue section of human brain. Samples were incubated in FMN2 polyclonal antibody (Product # PA5-23251) using a dilution of 1:300. The signal was developed using HRP-labeled secondary and DAB reagent which followed counterstaining of nuclei with hematoxylin. This FMN2 antibody generated a nuclear and cytoplasmic staining primarily in the glial cells.
Product Details
PA5-23251
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to amino acids 657-688 of human FMN2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
PBS
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Sequence homology: Mouse, Rat (77%).
Target Information
FMN2, a novel formin homology protein of the cappuccino subfamily, is highly conserved between evolutionarily diverse vertebrates. FMN2 bears a high degree of similarity to formin-1 which is the founding member of formin homology proteins. FMN2 plays a crucial role in maintenance of the meiotic spindle. The protein is widely expressed in human fetal brain, adult whole brain, hypothalamus, retina, pancreatic islet and germinal-center B cells. Pathological role of the protein is identified in various tumors like parathyloid tumor, glioblastoma, retinoblastoma and chondrosarcoma. FMN2 mutations are often a cause of unexplained infertility in women. The gene encoding for human FMN2 is localized in the chromosomal region 1q43.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Formin-2; RP11-90L13.1; unnamed protein product
Gene Aliases: FMN2
UniProt ID: (Human) Q9NZ56
Entrez Gene ID: (Human) 56776
cellular response to DNA damage stimulus
protein transport
vesicle-mediated transport
meiotic chromosome movement towards spindle pole
cell migration
actin cytoskeleton organization
intracellular signal transduction
polar body extrusion after meiotic divisions
negative regulation of protein catabolic process
negative regulation of apoptotic process
intracellular transport
oogenesis
actin filament bundle assembly
establishment of meiotic spindle localization
homologous chromosome movement towards spindle pole involved in homologous chromosome segregation
formin-nucleated actin cable assembly
cellular response to hypoxia
positive regulation of double-strand break repair
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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