Immunogen sequence: KPTLAIIGLI KPLGSMIPTG ETQARWAVRV LKGVNKLPPP SVMIEEINAR KENKPSWFGL CYCKALQSDY ITYIDELLTY INAKPNLFSM LLTDPHLALT VFFGPCSPYQ FRLTGPGKWE GARNAIMTQW DRTFKVIKAR VVQESPSPFE SFLKVFSFLA LLVAIFLIFL; Positive Samples: Mouse liver; Cellular Location: Endoplasmic reticulum membrane, Microsome membrane
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.
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Protein Aliases: Dimethylaniline monooxygenase [N-oxide-forming] 1; Dimethylaniline oxidase 1; Fetal hepatic flavin-containing monooxygenase 1; Flavin-containing monooxygenase 1 (fetal liver); FMO 1; Hepatic flavin-containing monooxygenase 1
Gene Aliases: Fmo-1; FMO1