Recommended positive controls: 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (83%), Rat (82%), Rabbit (84%), Rhesus Monkey (96%), Chimpanzee (99%), Bovine (81%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
The flavin-containing monooxygenases are NADPH-dependent enzymes that catalyze the oxidation of many drugs and xenobiotics. In most mammals, there is a flavin-containing monooxygenase that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, in humans, this enzyme is truncated and is probably rapidly degraded. The protein encoded by this gene represents the truncated form and apparently has no catalytic activity. A functional allele found in African Americans has been reported, but no sequence evidence has been deposited to support the finding. This gene is found in a cluster with the FMO1, FMO3, and FMO4 genes on chromosome 1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dimethylaniline monooxygenase [N-oxide-forming] 2; Dimethylaniline oxidase 2; flavin containing monooxygenase 2 (non-functional); FMO 1B1; FMO 2; FMO, pulmonary; Pulmonary flavin-containing monooxygenase 2
Gene Aliases: FMO1B1; FMO2
UniProt ID: (Human) Q99518
Entrez Gene ID: (Human) 2327