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Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
FMRP Fusion Protein Ag4697 (1-297 aa encoded by BC038998) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.24 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MEELVVEVR GSNGAFYKAF VKDVHEDSIT VAFENNWQPD RQIPFHDVRF PPPVGYNKDI NESDEVEVYS RANEKEPCCW WLAKVRMIKG EFYVIEYAAC DATYNEIVTI ERLRSVNPNK PATKDTFHKI KLDVPEDLRQ MCAKEAAHKD FKKAVGAFSV TYDPENYQLV ILSINEVTSK RAHMLIDMHF RSLRTKLSLI MRNEEASKQL ESSRQLASRF HEQFIVREDL MGLAIGTHGA NIQQARKVPG VTAIDLDEDT CTFHIYGEDQ DAVKKARSFL EFAEDVIQVP RNLVGLKI (1-297 aa encoded by BC038998)
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FMRP; fragile X mental retardation protein 1; fragile X mental retardation protein 1 homolog; Fragile X messenger ribonucleoprotein; Fragile X messenger ribonucleoprotein 1; MGC87458; Protein FMR-1
Gene Aliases: Fmr-1; FMR1; FMRP; FRAXA; POF; POF1
UniProt ID: (Human) Q06787
Entrez Gene ID: (Human) 2332, (Mouse) 14265
Molecular Function:
translation factor
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