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Proteintech
FMRP Polyclonal Antibody
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Product Details
13755-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FMRP Fusion Protein Ag4697 (1-297 aa encoded by BC038998)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Amount
36 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEELVVEVR GSNGAFYKAF VKDVHEDSIT VAFENNWQPD RQIPFHDVRF PPPVGYNKDI NESDEVEVYS RANEKEPCCW WLAKVRMIKG EFYVIEYAAC DATYNEIVTI ERLRSVNPNK PATKDTFHKI KLDVPEDLRQ MCAKEAAHKD FKKAVGAFSV TYDPENYQLV ILSINEVTSK RAHMLIDMHF RSLRTKLSLI MRNEEASKQL ESSRQLASRF HEQFIVREDL MGLAIGTHGA NIQQARKVPG VTAIDLDEDT CTFHIYGEDQ DAVKKARSFL EFAEDVIQVP RNLVGLKI (1-297 aa encoded by BC038998)
Target Information
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FMRP; FMRP translational regulator 1; fragile X mental retardation protein 1 homolog; Fragile X messenger ribonucleoprotein; Fragile X messenger ribonucleoprotein 1; mFmr1p; MGC87458; Protein FMR-1; synaptic functional regulator FMR1; unnamed protein product
Gene Aliases: Fmr-1; FMR1; FMRP; FRAXA; POF; POF1
UniProt ID: (Human) Q06787, (Mouse) P35922
Entrez Gene ID: (Human) 2332, (Mouse) 14265
G-quadruplex RNA binding
nucleic acid binding
chromatin binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
protein binding
microtubule binding
poly(U) RNA binding
translation repressor activity
translation initiation factor binding
RNA strand annealing activity
poly(G) binding
siRNA binding
miRNA binding
signaling adaptor activity
RNA stem-loop binding
identical protein binding
protein homodimerization activity
ribosome binding
ion channel binding
macromolecular complex binding
translation regulator activity
protein heterodimerization activity
mRNA 5'-UTR binding
dynein complex binding
histone H3 reader activity
molecular condensate scaffold activity
N6-methyladenosine-containing RNA binding
sequence-specific mRNA binding
poly(A) RNA binding
translation factor
deadenylation-dependent decapping of nuclear-transcribed mRNA
regulation of alternative mRNA splicing, via spliceosome
positive regulation of receptor internalization
DNA repair
chromatin organization
mRNA processing
mRNA export from nucleus
regulation of translation
cellular response to DNA damage stimulus
glutamate receptor signaling pathway
nervous system development
RNA splicing
regulation of cell communication
negative regulation of translation
gene silencing by RNA
stress granule assembly
regulation of mRNA stability
modulation by host of viral RNA genome replication
positive regulation of translation
negative regulation of translational initiation
regulation of neurotransmitter secretion
positive regulation of long-term neuronal synaptic plasticity
animal organ development
mRNA transport
positive regulation of cellular component organization
regulation of filopodium assembly
positive regulation of filopodium assembly
negative regulation of gene silencing by miRNA
regulation of dendritic spine development
positive regulation of dendritic spine development
regulation of biological quality
cellular response to virus
regulation of neuronal action potential
regulation of translation at presynapse, modulating synaptic transmission
membraneless organelle assembly
negative regulation of long term synaptic depression
positive regulation of intracellular transport of viral material
negative regulation of voltage-gated calcium channel activity
positive regulation of proteasomal protein catabolic process
negative regulation of synaptic vesicle exocytosis
positive regulation of gene silencing by miRNA
negative regulation of cytoplasmic translation
transport
central nervous system development
dendritic spine development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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