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Proteintech
FMRP Polyclonal Antibody
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Product Details
13755-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FMRP Fusion Protein Ag4697 (1-297 aa encoded by BC038998)
Conjugate
Form
Liquid
Concentration
0.24 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEELVVEVR GSNGAFYKAF VKDVHEDSIT VAFENNWQPD RQIPFHDVRF PPPVGYNKDI NESDEVEVYS RANEKEPCCW WLAKVRMIKG EFYVIEYAAC DATYNEIVTI ERLRSVNPNK PATKDTFHKI KLDVPEDLRQ MCAKEAAHKD FKKAVGAFSV TYDPENYQLV ILSINEVTSK RAHMLIDMHF RSLRTKLSLI MRNEEASKQL ESSRQLASRF HEQFIVREDL MGLAIGTHGA NIQQARKVPG VTAIDLDEDT CTFHIYGEDQ DAVKKARSFL EFAEDVIQVP RNLVGLKI (1-297 aa encoded by BC038998)
Target Information
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: FMRP; fragile X mental retardation protein 1; fragile X mental retardation protein 1 homolog; Fragile X messenger ribonucleoprotein; Fragile X messenger ribonucleoprotein 1; MGC87458; Protein FMR-1
Gene Aliases: Fmr-1; FMR1; FMRP; FRAXA; POF; POF1
UniProt ID: (Human) Q06787
Entrez Gene ID: (Human) 2332, (Mouse) 14265
G-quadruplex RNA binding
chromatin binding
RNA binding
mRNA binding
mRNA 3'-UTR binding
protein binding
microtubule binding
poly(U) RNA binding
translation repressor activity
translation initiation factor binding
RNA strand annealing activity
poly(G) binding
methylated histone binding
siRNA binding
miRNA binding
RNA stem-loop binding
identical protein binding
protein homodimerization activity
ribosome binding
ion channel binding
poly(A) RNA binding
dynein binding
protein heterodimerization activity
mRNA 5'-UTR binding
sequence-specific mRNA binding
nucleic acid binding
translation factor
regulation of alternative mRNA splicing, via spliceosome
positive regulation of receptor internalization
mRNA processing
cellular response to DNA damage stimulus
glutamate receptor signaling pathway
RNA splicing
negative regulation of translation
gene silencing by RNA
positive regulation of histone phosphorylation
cellular response to UV
regulation of mRNA stability
modulation by host of viral RNA genome replication
positive regulation of translation
negative regulation of translational initiation
regulation of neurotransmitter secretion
mRNA transport
regulation of filopodium assembly
positive regulation of filopodium assembly
regulation of gene silencing by miRNA
regulation of dendritic spine development
positive regulation of dendritic spine development
cellular response to hydroxyurea
cellular response to virus
regulation of neuronal action potential
negative regulation of long term synaptic depression
positive regulation of intracellular transport of viral material
negative regulation of voltage-gated calcium channel activity
positive regulation of proteasomal protein catabolic process
positive regulation of mRNA binding
negative regulation of synaptic vesicle exocytosis
positive regulation of gene silencing by miRNA
negative regulation of cytoplasmic translation
positive regulation of response to DNA damage stimulus
transport
central nervous system development
dendritic spine development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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