This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. View Details
For Western Blot, this antibody has non-specific bands at 13 kDa,32 kDa and 68 kDa.
Heat mediated antigen retrieval recommended prior to tissue staining.
This antibody is predicted to react with orangutan based on sequence homology.
FMR1 binds RNA and is associated with polysomes. The protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure. Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FMRP; Fragile X mental retardation protein 1; Fragile X mental retardation protein 1 homolog; fragile X mental retardation syndrome 1 homolog; fragile X mental retardation-1 protein; MGC87458; protein FMR-1; ragile X mental retardation protein; Synaptic functional regulator FMR1
Gene Aliases: Fmr-1; FMR1; FMRP; FRAXA; POF; POF1
Molecular Function: translation factor