Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Immunogen sequence: IKDNDSNNNP KEKGKGPEQS PQGRPVGTRQ KKSPSINTID V
Highest antigen sequence identity to the following orthologs: Mouse - 98%, Rat - 100%.
Acts as an anti-inflammatory factor in the intestine and colon. Binds to and acts on macrophages to downregulate pro-inflammatory gene expression. Affects key macrophage functions, including phagocytosis, by downregulating many key pathways for macrophage activation, partly via by STAT3 activation and signaling. May be required to dampen the immunological response in colitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Fibronectin type III domain-containing protein 4; Fibronectin type III repeat-containing protein 1
Gene Aliases: FNDC4; FRCP1; UNQ6389/PRO21134
UniProt ID: (Human) Q9H6D8
Entrez Gene ID: (Human) 64838
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