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Bethyl Laboratories
FNIP1 Polyclonal Antibody
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Product Details
A305-767A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A region between residue 775 to 825 of human Folliculin-interacting protein 1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7.0 to 8.0
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
FNIP1 encodes a protein that binds to the tumor suppressor protein folliculin and to AMP-activated protein kinase (AMPK). The encoded protein participates in the regulation of cellular metabolism and nutrient sensing by modulating the AMPK and target of rapamycin signaling pathways. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. Diseases associated with FNIP1 include Birt-Hogg-Dube Syndrome and Pleural Disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Folliculin-interacting protein 1; unnamed protein product
Gene Aliases: FNIP1; IMD93; KIAA1961
UniProt ID: (Human) Q8TF40
Entrez Gene ID: (Human) 96459
negative regulation of transcription from RNA polymerase II promoter
B cell apoptotic process
immature B cell differentiation
positive regulation of B cell apoptotic process
lysosome organization
negative regulation of cell proliferation
cellular response to starvation
B cell differentiation
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein complex assembly
protein destabilization
cellular response to nutrient levels
TOR signaling
negative regulation of TOR signaling
positive regulation of TOR signaling
TORC1 signaling
negative regulation of protein localization to nucleus
positive regulation of TORC1 signaling
negative regulation of lysosome organization
regulation of pro-B cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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