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Invitrogen
FNIP2 Polyclonal Antibody
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Product Details
PA5-20690
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A 16 amino acid peptide near the carboxy terminus of human FNIP2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS
Contains
0.02% sodium azide
Storage conditions
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
A suggested positive control is rat skeletal muscle tissue lysate.
PA5-20690 can be used with blocking peptide PEP-0805.
Target Information
FNIP2 is the second protein found to interact with folliculin, the product of the Birt-Hogg-Dube (BHD) gene. Folliculin is thought to act as a tumor suppressor as mutations or loss of heterozygosity in this gene are associated with BHD syndrome-related renal tumors. Folliculin and FNIP1, a protein that shares 49% identity to FNIP2, bind to AMPK, an important energy sensor in cells that negatively regulates the mammalian target of rapamycin (mTOR), a protein that is thought to be the master switch for cell growth and proliferation. FNIP1 and FNIP2 are able to form homo- and heteromeric multimers, suggesting these proteins may have a functional relationship.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FNIP1-like protein; Folliculin-interacting protein 2; O6-methylguanine-induced apoptosis 1 protein
Gene Aliases: D630023B12Rik; FNIP2; FNIPL; KIAA1450; MAPO1; mKIAA1450; RGD1562174
UniProt ID: (Human) Q9P278, (Mouse) Q80TD3
Entrez Gene ID: (Human) 57600, (Rat) 310538, (Mouse) 329679
negative regulation of transcription from RNA polymerase II promoter
regulation of protein phosphorylation
protein phosphorylation
intrinsic apoptotic signaling pathway in response to DNA damage
positive regulation of peptidyl-serine phosphorylation
cellular response to DNA damage stimulus
positive regulation of protein complex assembly
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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