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Invitrogen
FNTA Polyclonal Antibody
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FIGURE: 1 / 1
FNTA Antibody (PA5-97159) in WB
Western blot analysis of FNTA in extracts of various cell lines. Samples were incubated with FNTA Polyclonal antibody (Product # PA5-97159) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.
Product Details
PA5-97159
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein (or fragment)
Conjugate
Form
Liquid
Concentration
1.45 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: LKGILQDRGL SKYPNLLNQL LDLQPSHSSP YLIAFLVDIY EDMLENQCDN KEDILNKALE LCEILAKEKD TIRKEYWRYI GRSLQSKHST ENDSPTNVQQ; Positive Samples: HeLa, HT-29, A-549, HL-60, Mouse heart, Mouse kidney, Rat brain
Target Information
FNTA (Farnesyltransferase, CAAX box; alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/ geranyl geranyl transferase type I alpha subunit(PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit) is located locus 8p11 (human). Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2. 5. 1. 21), which is alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box. FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases. Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CAAX farnesyltransferase subunit alpha; farnesyl-protein transferase alpha-subunit; farnesyltransferase, CAAX box, alpha; Farnesyltransferase, subunit alpha; FTase-alpha; GGTase-I-alpha; Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; protein prenyltransferase alpha subunit repeat containing 2; Ras proteins prenyltransferase subunit alpha; type I protein geranyl-geranyltransferase alpha subunit; Type I protein geranyl-geranyltransferase subunit alpha; unnamed protein product
Gene Aliases: FNTA; FPTA; FTA; PFAS; PGGT1A; PTAR2
UniProt ID: (Human) P49354, (Rat) Q04631, (Mouse) Q61239
Entrez Gene ID: (Human) 2339, (Rat) 25318, (Mouse) 14272
prenyltransferase activity
protein farnesyltransferase activity
protein geranylgeranyltransferase activity
CAAX-protein geranylgeranyltransferase activity
Rab geranylgeranyltransferase activity
protein binding
microtubule binding
protein prenyltransferase activity
acetyltransferase activator activity
transferase activity
enzyme binding
receptor tyrosine kinase binding
alpha-tubulin binding
binding, bridging
drug binding
zinc ion binding
isoprenoid binding
acetylcholine receptor regulator activity
peptide binding
acyltransferase
nuclear envelope organization
enzyme linked receptor protein signaling pathway
transforming growth factor beta receptor signaling pathway
peptide pheromone maturation
neuromuscular junction development
protein farnesylation
protein geranylgeranylation
positive regulation of Rac protein signal transduction
protein maturation
regulation of microtubule-based movement
skeletal muscle acetylcholine-gated channel clustering
positive regulation of skeletal muscle acetylcholine-gated channel clustering
positive regulation of cell proliferation
response to inorganic substance
regulation of receptor activity
response to organic cyclic compound
response to cytokine
negative regulation of apoptotic process
neurotransmitter receptor metabolic process
positive regulation of cell cycle
positive regulation of nitric-oxide synthase biosynthetic process
negative regulation of nitric-oxide synthase biosynthetic process
positive regulation of tubulin deacetylation
positive regulation of deacetylase activity
protein prenylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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