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FOXA2/HNF 3beta Polyclonal Antibody

View all (34) FOXA2 antibodies

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FOXA2/HNF 3beta Polyclonal Antibody

Product Details

BS-2358R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:300
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Flow Cytometry (Flow)

1:100
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human HNF 3 beta, amino acids 201-300.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin. They also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. FOXA2 has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FKHL20; Forkhead box protein A2; hepatic nuclear factor-3-beta; hepatocyte nuclear factor 3 beta (winged helix transcription factor); hepatocyte nuclear factor 3, beta; Hepatocyte nuclear factor 3-beta; HNF-3-beta; HNF-3B; MGC19807; RONU; TCF-3B; Transcription factor 3B; unnamed protein product; WHN

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Gene Aliases: FOXA2; HNF-3-beta; Hnf-3b; HNF3-beta; HNF3B; HNF3beta; Tcf-3b; TCF3B

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UniProt ID: (Human) Q9Y261, (Mouse) A2AR89, (Rat) P32182

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Entrez Gene ID: (Human) 3170, (Mouse) 15376, (Rat) 25099

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding nucleic acid binding DNA binding transcription factor activity, sequence-specific DNA binding transcription corepressor activity protein binding protein domain specific binding sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding sequence-specific double-stranded DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding double-stranded DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding kinase binding transcription regulatory region DNA binding SMAD binding winged helix/forkhead transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter cell fate specification chromatin organization regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter adult locomotory behavior anatomical structure morphogenesis negative regulation of epithelial to mesenchymal transition cell differentiation regulation of blood coagulation endocrine pancreas development positive regulation of embryonic development positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of insulin secretion involved in cellular response to glucose stimulus response to interleukin-6 dopaminergic neuron differentiation primitive streak formation positive regulation of cell-cell adhesion mediated by cadherin positive regulation of gastrulation positive regulation of transcription from RNA polymerase II promoter by glucose negative regulation of transcription from RNA polymerase II promoter by glucose in utero embryonic development ectoderm formation transcription, DNA-templated transcription from RNA polymerase II promoter Notch signaling pathway multicellular organism development pattern specification process anterior/posterior pattern specification dorsal/ventral pattern formation regulation of gene expression chromatin modification regulation of lipid metabolic process regulation of steroid metabolic process cell differentiation in hindbrain dorsal/ventral neural tube patterning signal transduction involved in regulation of gene expression lung development somite rostral/caudal axis specification negative regulation of glucokinase activity negative regulation of sequence-specific DNA binding transcription factor activity negative regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of smoothened signaling pathway positive regulation of transcription from RNA polymerase III promoter cell development anatomical structure formation involved in morphogenesis neuron fate specification epithelial tube branching involved in lung morphogenesis lung epithelial cell differentiation connective tissue development negative regulation of detection of glucose response to insulin
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