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Invitrogen
FOXC1 Polyclonal Antibody
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FIGURE: 1 / 3
FOXC1 Antibody (PA5-68774) in WB
Western blot was performed using Anti-FOXC1 Polyclonal Antibody (Product # PA5-68774) and a 56.7 kDa band corresponding to FOXC1 was observed across all cell lines tested, except MCF10A and MIA PaCa-2. whole cell extracts (40 µg lysate) of Hep G2 (Lane 1), Hep G2 treated with IL-8 (50 ng/mL, 24hrs) (Lane 2), A549 (Lane 3), MCF10A (Lane 4), MIA PaCa-2 (Lane 5) were electrophoresed using NuPAGE™10% Bis-Tris Protein Gel (Product # NP0301BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® ... View More
Product Details
PA5-68774
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
synthetic peptide directed towards the n terminal region of mouse FOXC1
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This target displays homology in the following species: Cow: 86%; Dog: 86%; Horse: 86%; Human: 100%; Mouse: 100%; Rat: 100%; Zebrafish: 100%
Target Information
FOXC1 is a protein belonging to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this protein is not known, however, it plays a role in the regulation of FGF19-FGFR4-MAPK pathway to promote both the development and maintenance of anterior segment structures within the eye. Mutations in this gene cause various glaucoma, iridogoniodysgenesis anomaly, Peters anomaly that includes central corneal leukoma, absence of the posterior corneal stroma and Descemetmembrane and Axenfeld-Rieger anomaly characterized by posterior corneal embryotoxon, iris adhesion to the Schwalbe line, hypertelorism, hypoplasia of the malar bones, congenital absence of some teeth and mental retardation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: congenital hydrocephalus; Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; HGNC:3800; Mesoderm/mesenchyme forkhead 1; MF-1; Transcription factor FKH-1
Gene Aliases: ch; fkh-1; Fkh1; Fkhl7; Foxc1; FREAC3; frkhda; Mf1; Mf4
UniProt ID: (Mouse) Q61572
Entrez Gene ID: (Mouse) 17300
RNA polymerase II regulatory region sequence-specific DNA binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor binding
DNA binding, bending
sequence-specific DNA binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
skeletal system development
ossification
ovarian follicle development
blood vessel development
eye development
ureteric bud development
in utero embryonic development
somitogenesis
kidney development
lymph vessel development
blood vessel remodeling
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
brain development
heart development
cell proliferation
germ cell migration
positive regulation of gene expression
mesenchymal cell development
neural crest cell development
cell migration
negative regulation of angiogenesis
collagen fibril organization
glycosaminoglycan metabolic process
lacrimal gland development
embryonic heart tube development
maintenance of lens transparency
vascular endothelial growth factor signaling pathway
odontogenesis of dentin-containing tooth
camera-type eye development
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
regulation of organ growth
vascular endothelial growth factor receptor signaling pathway
paraxial mesoderm formation
mesenchymal cell differentiation
artery morphogenesis
regulation of blood vessel size
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
negative regulation of lymphangiogenesis
positive regulation of hematopoietic progenitor cell differentiation
positive regulation of hematopoietic stem cell differentiation
negative regulation of apoptotic process involved in outflow tract morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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