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Invitrogen

FOXC1/FOXC2 Polyclonal Antibody

View all (2) FOXC1/FOXC2 antibodies

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FOXC1/FOXC2 Polyclonal Antibody

Product Details

PA5-101153

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FOXC1(Accession Q12948), corresponding to amino acid residues N118-L168.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2850597

Product Specific Information

Antibody detects endogenous levels of total FOXC1/2.

Target Information

The forkhead transcription factor genes FOXC1 (Mf1) and FOXC2 (Mfh1) interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop. The genes have similar, dose-dependent functions, and compensate for each other in the early development of the heart, blood vessels and somites. Both FOXC1 and FOXC2 are expressed in the mesenchyme from which the ocular drainage structures derive. FOXC1 and FOXC2 also interact in kidney and heart development. Mutations in the FOXC1 gene result in Axenfeld-Rieger malformations of the anterior segment of the eye and lead to an increased susceptibility of glaucoma, including juvenile glaucoma. Functional regions in FOXC1 are required for nuclear localization and transcriptional regulation. Specifically, two regions in the FOXC1 forkhead domain, one rich in basic amino acid residues, and a second, highly conserved among all FOX proteins, are necessary for nuclear localization of the FOXC1 protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BF-3; Brain factor 3; congenital hydrocephalus; forkhead box C1 protein; forkhead box C2 (MFH-1 mesenchyme forkhead 1); forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C1; Forkhead box protein C2; forkhead homolog 14; forkhead, Drosophila, homolog-like 14; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL14; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FOXC1; FREAC-3; HFH-BF-3; Mesenchyme fork head protein 1; mesenchyme forkhead 1; Mesoderm/mesenchyme forkhead 1; MF-1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; myeloid factor-delta; Transcription factor FKH-1; Transcription factor FKH-14

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Gene Aliases: ARA; ASGD3; ch; fkh-1; Fkh1; Fkh14; FKHL14; FKHL7; FOXC1; FOXC2; FREAC-3; FREAC3; frkhda; Hfhbf3; IGDA; IHG1; IRID1; LD; Mf1; Mf4; MFH-1; MFH1; RIEG3

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UniProt ID: (Human) Q12948, (Human) Q99958, (Mouse) Q61572, (Rat) Q63246, (Mouse) Q61850

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Entrez Gene ID: (Human) 2296, (Human) 2303, (Mouse) 17300, (Rat) 364706, (Rat) 171356, (Mouse) 14234

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding DNA binding, bending sequence-specific DNA binding RNA polymerase II sequence-specific DNA binding transcription factor binding DNA-binding transcription factor binding promoter-specific chromatin binding bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding chromatin DNA binding identical protein binding sequence-specific double-stranded DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding transcription regulatory region DNA binding molecular_function transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding winged helix/forkhead transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development ossification angiogenesis ovarian follicle development blood vessel development eye development ureteric bud development in utero embryonic development somitogenesis kidney development lymph vessel development endochondral ossification blood vessel remodeling heart morphogenesis apoptotic process involved in outflow tract morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter Notch signaling pathway brain development heart development cell proliferation germ cell migration anatomical structure morphogenesis positive regulation of gene expression positive regulation of epithelial to mesenchymal transition mesenchymal cell development neural crest cell development cell migration negative regulation of angiogenesis cerebellum development cell differentiation collagen fibril organization glycosaminoglycan metabolic process lacrimal gland development embryonic heart tube development maintenance of lens transparency vascular endothelial growth factor signaling pathway odontogenesis of dentin-containing tooth camera-type eye development positive regulation of DNA binding positive regulation of keratinocyte differentiation positive regulation of transcription, DNA-templated negative regulation of mitotic cell cycle positive regulation of transcription from RNA polymerase II promoter regulation of organ growth vascular endothelial growth factor receptor signaling pathway paraxial mesoderm formation mesenchymal cell differentiation artery morphogenesis ventricular cardiac muscle tissue morphogenesis cardiac muscle cell proliferation chemokine-mediated signaling pathway cellular response to epidermal growth factor stimulus glomerular epithelium development regulation of blood vessel diameter negative regulation of lymphangiogenesis positive regulation of hematopoietic progenitor cell differentiation positive regulation of hematopoietic stem cell differentiation negative regulation of apoptotic process involved in outflow tract morphogenesis positive regulation of core promoter binding cellular response to chemokine patterning of blood vessels metanephros development lymphangiogenesis mesoderm development insulin receptor signaling pathway response to hormone positive regulation of endothelial cell migration positive regulation of cell adhesion mediated by integrin positive regulation of vascular wound healing paraxial mesodermal cell fate commitment embryonic cranial skeleton morphogenesis embryonic viscerocranium morphogenesis embryonic skeletal system morphogenesis glomerular endothelium development glomerular visceral epithelial cell differentiation glomerular mesangial cell development positive regulation of cell migration involved in sprouting angiogenesis negative regulation of cold-induced thermogenesis transcription, DNA-templated transcription from RNA polymerase II promoter regulation of blood vessel size biological_process multicellular organism development positive regulation of integrin activation
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