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Product Details
PA5-36261
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to amino acids 100-150 of human FoxC1
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2553446
Product Specific Information
This antibody detects endogenous protein at a molecular weight of 57 kDa.
Purity is >95% by SDS-PAGE.
Target Information
The forkhead transcription factor genes FOXC1 (Mf1) and FOXC2 (Mfh1) interact with the Notch signaling pathway and are required for the prepatterning of anterior and posterior domains in the presumptive somites through a putative Notch/Delta/Mesp regulatory loop. The genes have similar, dose-dependent functions, and compensate for each other in the early development of the heart, blood vessels and somites. Both FOXC1 and FOXC2 are expressed in the mesenchyme from which the ocular drainage structures derive. FOXC1 and FOXC2 also interact in kidney and heart development. Mutations in the FOXC1 gene result in Axenfeld-Rieger malformations of the anterior segment of the eye and lead to an increased susceptibility of glaucoma, including juvenile glaucoma. Functional regions in FOXC1 are required for nuclear localization and transcriptional regulation. Specifically, two regions in the FOXC1 forkhead domain, one rich in basic amino acid residues, and a second, highly conserved among all FOX proteins, are necessary for nuclear localization of the FOXC1 protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BF-3; Brain factor 3; congenital hydrocephalus; forkhead box C1 protein; forkhead box C2 (MFH-1 mesenchyme forkhead 1); forkhead box C2 (MFH-1, mesenchyme forkhead 1); Forkhead box protein C1; Forkhead box protein C2; forkhead homolog 14; forkhead, Drosophila, homolog-like 14; forkhead, drosophila, homolog-like 7; forkhead-related activator 3; Forkhead-related protein FKHL14; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; forkhead/winged helix-like transcription factor 7; FREAC-3; HFH-BF-3; Mesenchyme fork head protein 1; mesenchyme forkhead 1; Mesoderm/mesenchyme forkhead 1; MF-1; MFH-1 protein; MFH-1,mesenchyme forkhead 1; myeloid factor-delta; Transcription factor FKH-1; Transcription factor FKH-14
Gene Aliases: ARA; ch; fkh-1; Fkh1; Fkh14; FKHL14; FKHL7; FOXC1; FOXC2; FREAC-3; FREAC3; frkhda; Hfhbf3; IGDA; IHG1; IRID1; LD; Mf1; Mf4; MFH-1; MFH1; RIEG3
UniProt ID: (Human) Q12948, (Human) Q99958, (Mouse) Q61572, (Rat) Q63246, (Mouse) Q61850
Entrez Gene ID: (Human) 2296, (Human) 2303, (Mouse) 17300, (Rat) 364706, (Rat) 171356, (Mouse) 14234
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
protein binding
transcription factor binding
DNA binding, bending
sequence-specific DNA binding
transcription regulatory region DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin DNA binding
identical protein binding
molecular_function
winged helix/forkhead transcription factor
skeletal system development
ossification
ovarian follicle development
eye development
ureteric bud development
in utero embryonic development
somitogenesis
lymph vessel development
blood vessel remodeling
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
brain development
heart development
cell proliferation
germ cell migration
mesenchymal cell development
neural crest cell development
cell migration
negative regulation of angiogenesis
collagen fibril organization
glycosaminoglycan metabolic process
lacrimal gland development
embryonic heart tube development
maintenance of lens transparency
vascular endothelial growth factor signaling pathway
odontogenesis of dentin-containing tooth
camera-type eye development
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
regulation of organ growth
vascular endothelial growth factor receptor signaling pathway
paraxial mesoderm formation
artery morphogenesis
regulation of blood vessel size
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
negative regulation of lymphangiogenesis
positive regulation of hematopoietic progenitor cell differentiation
positive regulation of hematopoietic stem cell differentiation
negative regulation of apoptotic process involved in outflow tract morphogenesis
negative regulation of transcription from RNA polymerase II promoter
patterning of blood vessels
metanephros development
lymphangiogenesis
mesoderm development
insulin receptor signaling pathway
response to hormone
positive regulation of endothelial cell migration
positive regulation of cell adhesion mediated by integrin
positive regulation of vascular wound healing
paraxial mesodermal cell fate commitment
embryonic viscerocranium morphogenesis
glomerular endothelium development
glomerular visceral epithelial cell differentiation
glomerular mesangial cell development
positive regulation of cell migration involved in sprouting angiogenesis
blood vessel development
kidney development
heart morphogenesis
transcription, DNA-templated
positive regulation of gene expression
mesenchymal cell differentiation
regulation of transcription from RNA polymerase II promoter
biological_process
embryonic cranial skeleton morphogenesis
embryonic skeletal system morphogenesis
multicellular organism development
positive regulation of integrin activation
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