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Product Details
PA5-113676
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal region of Mouse Foxc2
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2884191
Product Specific Information
Immunogen sequence: GMGRSYAPYH HQPAAPKDLV KPPYSYIALI TMAIQNAPEK KITLNGIYQF
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Cow: 93%; Dog: 93%; Guinea Pig: 93%; Horse: 93%; Human: 93%; Mouse: 100%; Rat: 100%
Target Information
Forkhead box protein C2 (FOXC2) is a transciptional activator and is characterized by a distinct DNA-binding forkhead domain. FOXC2 may be involved in the formation of special mesenchymal tissues. Mutations affecting the gene can cause lymphedema-distichiasis (LYD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BF-3; Brain factor 3; Forkhead box protein C2; forkhead homolog 14; Forkhead-related protein FKHL14; Mesenchyme fork head protein 1; MFH-1 protein; Transcription factor FKH-14
Gene Aliases: Fkh14; Fkhl14; Foxc2; Hfhbf3; MFH-1; Mfh1
UniProt ID: (Mouse) Q61850
Entrez Gene ID: (Mouse) 14234
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
chromatin DNA binding
sequence-specific DNA binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
negative regulation of transcription from RNA polymerase II promoter
skeletal system development
ossification
blood vessel development
patterning of blood vessels
metanephros development
ureteric bud development
somitogenesis
kidney development
lymph vessel development
lymphangiogenesis
blood vessel remodeling
heart morphogenesis
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
Notch signaling pathway
multicellular organism development
heart development
cell proliferation
insulin receptor signaling pathway
response to hormone
positive regulation of endothelial cell migration
neural crest cell development
collagen fibril organization
positive regulation of integrin activation
positive regulation of cell adhesion mediated by integrin
embryonic heart tube development
positive regulation of vascular wound healing
camera-type eye development
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of organ growth
vascular endothelial growth factor receptor signaling pathway
paraxial mesoderm formation
paraxial mesodermal cell fate commitment
embryonic cranial skeleton morphogenesis
embryonic viscerocranium morphogenesis
embryonic skeletal system morphogenesis
artery morphogenesis
regulation of blood vessel size
ventricular cardiac muscle tissue morphogenesis
cardiac muscle cell proliferation
glomerular endothelium development
glomerular visceral epithelial cell differentiation
glomerular mesangial cell development
positive regulation of cell migration involved in sprouting angiogenesis
negative regulation of apoptotic process involved in outflow tract morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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