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FOXD Polyclonal Antibody
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Product Details
BS-12193R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human FOXD1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Transcription factor required for formation of positional identity in the developing retina, regionalization of the optic chiasm and morphogenesis of the kidney. Can neutralize ectodermal cells directly. Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Probable transcription factor involved in embryogenesis and somatogenesis. FOXD1 is involved in regulating inflammation as well as kidney and retinal development. FOXD1 regulates the activity of NFAT and NFkB. Deficiency of FOXD1 results in multiorgan systemic inflammation, exaggerated Th cell-derived cytokine production, and T cell proliferation in autogolgous MLRs. In kidneys, FOXD1 controls the production of signals required for the normal transition of induced mesenchyme into tubular epithelium and full growth and branching of the collecting system. Deletion of FOXD1 results in renal abnormalities. FOXD2 acts as a modulator of T cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: autoimmune susceptibility 1; BF-2; Brain factor 2; Forkhead box protein D1; FORKHEAD BOX PROTEIN D1 (FORKHEAD-RELATED PROTEIN FKHL8) (FORKHEAD-RELATED TRANSCRIPTION FACTOR 4) (FREAC-4); Forkhead box protein D2; Forkhead box protein D3; Forkhead box protein D4; forkhead homolog 2; forkhead, drosophila, homolog-like 17; Forkhead, drosophila, homolog-like 8; forkhead, Drosophila, homolog-like 9; forkhead-like 17; forkhead-like 8; forkhead-related activator 4; forkhead-related activator 5; forkhead-related activator 9; Forkhead-related protein FKHL17; Forkhead-related protein FKHL8; Forkhead-related protein FKHL9; Forkhead-related transcription factor 4; Forkhead-related transcription factor 5; Forkhead-related transcription factor 9; FREAC-4; FREAC-5; FREAC-9; Hepatocyte nuclear factor 3 forkhead homolog 2; HFH-2; HFH-BF-2; HNF-3/forkhead homolog 2; HNF-3/forkhead homolog, brain factor 2; HNF3/FH transcription factor genesis; Mesoderm/mesenchyme forkhead 2; MF-2; Myeloid factor-alpha; Transcription factor FKH-2
Gene Aliases: AI385632; AI426778; AIS1; BF-2; CWH3; Fkh2; FKHL17; FKHL8; FKHL9; FOXD1; FOXD2; FOXD3; FOXD4; FOXD4A; FREAC-4; FREAC-5; FREAC-9; FREAC4; FREAC5; FREAC9; Genesis; Hfh10; HFH2; Hfhbf2; Mf2; VAMAS2
UniProt ID: (Human) Q16676, (Human) O60548, (Human) Q9UJU5, (Human) Q12950, (Mouse) Q61345, (Mouse) O35392, (Mouse) Q61060, (Mouse) Q60688
Entrez Gene ID: (Human) 2297, (Human) 2306, (Human) 27022, (Human) 2298, (Mouse) 15229, (Mouse) 17301, (Mouse) 15221, (Mouse) 14237
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
DNA binding, bending
sequence-specific DNA binding
protein binding
sequence-specific double-stranded DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
double-stranded DNA binding
transcription regulatory region DNA binding
winged helix/forkhead transcription factor
branching involved in ureteric bud morphogenesis
kidney development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
axon guidance
anatomical structure morphogenesis
positive regulation of gene expression
cell differentiation
positive regulation of BMP signaling pathway
luteinizing hormone secretion
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
canonical Wnt signaling pathway
dichotomous subdivision of terminal units involved in ureteric bud branching
nephrogenic mesenchyme development
metanephric nephron development
metanephric capsule development
metanephric capsule specification
pattern specification involved in metanephros development
positive regulation of kidney development
negative regulation of transcription from RNA polymerase II promoter
in utero embryonic development
transcription, DNA-templated
transcription from RNA polymerase II promoter
multicellular organism development
trophectodermal cell differentiation
embryonic placenta development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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