Positive Samples: U-251MG, SH-SY5Y, 293T, mouse brain, mouse kidney, mouse spleen, rat brain, rat kidney, rat spleen
CD20 is a non-glycosylated surface phosphoprotein that has a molecular weight range of 33-37 kDa depending on the degree of phosphorylation. CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.
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Protein Aliases: BF-1; BF-2; BF1; Brain factor 1; Brain factor 2; Forkhead box protein G1; Forkhead box protein G1A; Forkhead box protein G1B; Forkhead box protein G1C; forkhead-like 1; forkhead-like 2; forkhead-like 3; forkhead-like 4; forkhead-like transcription factor BF-1; Forkhead-related protein FKHL1; Forkhead-related protein FKHL2; Forkhead-related protein FKHL3; FoxG1; HFK1; HFK2; HFK3; HNF-3/forkhead homolog, brain factor 1; oncogene QIN; transcription factor BF-1
Gene Aliases: 2900064B05Rik; BF-1; BF1; BF1A; BF2; FHKL3; FKH2; FKHL1; FKHL2; FKHL3; FKHL4; FOXG1; FOXG1A; FOXG1B; FOXG1C; HBF-1; HBF-2; HBF-3; HBF-G2; HBF2; Hfh9; Hfhbf1; HFK1; HFK2; HFK3; KHL2; QIN; RATBF1A