FOXH1 is a member of the Forkhead-box (FOX) family of transcription factors and is the human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 plays an important role in mediating TGF-beta/activin signals through its interaction with the SMAD2-SMAD4 complex. It is expressed primarily during early development and localizes in the cytoplasm until it forms a complex with the SMAD proteins at which time it translocates to the nucleus to positively or negatively affect gene expression.
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Protein Aliases: contains winged-helix domain; etID62177.12; Fast-1; Forkhead activin signal transducer 1; Forkhead box protein H1; Schmalspur protein; transcription factor; uncle freddy; unf
Gene Aliases: fast; fast1; fe26b06; foxh1; schmalspur; SUR; wu:fe26b06; wu:fi30c08; wu:fi32b01
UniProt ID: (Zebrafish) Q9I9E1
Entrez Gene ID: (Zebrafish) 57930
Molecular Function: winged helix/forkhead transcription factor