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FOXM1 Polyclonal Antibody

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FOXM1 Antibody in Western Blot (WB) — Mouse spleen tissue were subjected to SDS PAGE followed by western blot with 13147-1-AP (FOXM1 antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

FOXM1 Antibody in Immunoprecipitation (IP) — IP result of anti-FOXM1 (IP:13147-1-AP, 5ug; Detection:13147-1-AP 1:700) with L02 cells lysate 1560ug.

Product Details

13147-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 12 publications 12 publications
Immunohistochemistry (IHC)	-	View 5 publications 5 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:400	-
Immunocytochemistry (ICC/IF)	-	View 1 publication 1 publication
Immunoprecipitation (IP)	0.5-4.0 µg	-
ChIP assay (ChIP)	Assay-dependent	View 1 publication 1 publication

Product Specifications
Species Reactivity	Human, Mouse
Published species	Human, Mouse
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	FOXM1 Fusion Protein Ag3729 (445-748 aa encoded by BC006192) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.29 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Product # 13147-1-AP is rabbit polyclonal antibody raised against C-terminal of human FOXM1. This antibody can recognize three kinds of FOXM1,FOXM1-pp (~95-110 kDa), FOXM1-B (isoform2,~83 kDa) and FOXM1A (isoform4, ~90 kDa)

Immunogen sequence: KEEEIQPGE EMPHLARPIK VESPPLEEWP SPAPSFKEES SHSWEDSSQS PTPRPKKSYS GLRSPTRCVS EMLVIQHRER RERSRSRRKQ HLLPPCVDEP ELLFSEGPST SRWAAELPFP ADSSDPASQL SYSQEVGGPF KTPIKETLPI SSTPSKSVLP RTPESWRLTP PAKVGGLDFS PVQTPQGASD PLPDPLGLMD LSTTPLQSAP PLESPQRLLS SEPLDLISVP FGNSSPSDID VPKPGSPEPQ VSGLAANRSL TEGLVLDTMN DSLSKILLDI SFPGLDEDPL GPDNINWSQF IPELQ (445-748 aa encoded by BC006192)

Target Information

FOXM1 (forkhead box protein M1) is a transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. FOXM1 plays a role in the control of cell proliferation and DNA break repairs participating in the DNA damage checkpoint response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Expression and functional characterization of FOXM1 in non-small cell lung cancer.

OncoTargets and therapy

Zhang Y,Qiao WB,Shan L

Fri Mar 18 00:00:00 EDT 2022

PARI functions as a new transcriptional target of FOXM1 involved in gastric cancer development.

International journal of biological sciences

Zhang Y,Ye X,Chen L,Wu Q,Gao Y,Li Y

Mon Jul 15 00:00:00 EDT 2019

Vagus-macrophage-hepatocyte link promotes post-injury liver regeneration and whole-body survival through hepatic FoxM1 activation.

Nature communications

Izumi T,Imai J,Yamamoto J,Kawana Y,Endo A,Sugawara H,Kohata M,Asai Y,Takahashi K,Kodama S,Kaneko K,Gao J,Uno K,Sawada S,Kalinichenko VV,Ishigaki Y,Yamada T,Katagiri H

Thu Dec 13 00:00:00 EST 2018

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence.

Nature communications

Macedo JC,Vaz S,Bakker B,Ribeiro R,Bakker PL,Escandell JM,Ferreira MG,Medema R,Foijer F,Logarinho E

Thu Jul 19 00:00:00 EDT 2018

FoxM1 repression during human aging leads to mitotic decline and aneuploidy-driven full senescence.

Nature communications

Macedo JC,Vaz S,Bakker B,Ribeiro R,Bakker PL,Escandell JM,Ferreira MG,Medema R,Foijer F,Logarinho E

Thu Jul 19 00:00:00 EDT 2018

3-O-acetyl-11-keto-β-boswellic acid exerts anti-tumor effects in glioblastoma by arresting cell cycle at G2/M phase.

Journal of experimental & clinical cancer research : CR

Li W,Liu J,Fu W,Zheng X,Ren L,Liu S,Wang J,Ji T,Du G

Tue Jul 03 00:00:00 EDT 2018

Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene during Infection.

Journal of virology

Fuller MS,Majumder K,Pintel DJ

Sat Jul 15 00:00:00 EDT 2017

Minute Virus of Mice Inhibits Transcription of the Cyclin B1 Gene during Infection.

Journal of virology

Fuller MS,Majumder K,Pintel DJ

Sat Jul 15 00:00:00 EDT 2017

FOXM1 regulates glycolysis in hepatocellular carcinoma by transactivating glucose transporter 1 expression.

Oncology reports

Shang R,Pu M,Li Y,Wang D

Sat Apr 01 00:00:00 EDT 2017

FOXM1 regulates glycolysis in hepatocellular carcinoma by transactivating glucose transporter 1 expression.

Oncology reports

Shang R,Pu M,Li Y,Wang D

Sat Apr 01 00:00:00 EDT 2017

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.

Nature communications

Zhu P,Wang Y,Wu J,Huang G,Liu B,Ye B,Du Y,Gao G,Tian Y,He L,Fan Z

Thu Dec 01 00:00:00 EST 2016

LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells.

Nature communications

Zhu P,Wang Y,Wu J,Huang G,Liu B,Ye B,Du Y,Gao G,Tian Y,He L,Fan Z

Thu Dec 01 00:00:00 EST 2016

Microarray-based gene expression profiling reveals genes and pathways involved in the oncogenic function of REG3A on pancreatic cancer cells.

Gene

Xu Q,Fu R,Yin G,Liu X,Liu Y,Xiang M

Thu Mar 10 00:00:00 EST 2016

POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation.

Nature communications

Wang B,Ma A,Zhang L,Jin WL,Qian Y,Xu G,Qiu B,Yang Z,Liu Y,Xia Q,Liu Y

Thu Oct 29 00:00:00 EDT 2015

Silibinin-induced glioma cell apoptosis by PI3K-mediated but Akt-independent downregulation of FoxM1 expression.

European journal of pharmacology

Zhang M,Liu Y,Gao Y,Li S

Thu Oct 15 00:00:00 EDT 2015

Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.

Pharmaceutical research

Chen X,Meng Q,Wang C,Liu Q,Sun H,Huo X,Sun P,Yang X,Peng J,Liu K

Sun Feb 01 00:00:00 EST 2015

Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.

Pharmaceutical research

Chen X,Meng Q,Wang C,Liu Q,Sun H,Huo X,Sun P,Yang X,Peng J,Liu K

Sun Feb 01 00:00:00 EST 2015

Effects of metformin on FOXM1 expression and on the biological behavior of acute leukemia cell lines.

Molecular medicine reports

Zhang B,Liu LL,Mao X,Zhang DH

Mon Dec 01 00:00:00 EST 2014

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell proliferation, migration and invasion in epithelial ovarian cancer.

Journal of translational medicine

Wen N,Wang Y,Wen L,Zhao SH,Ai ZH,Wang Y,Wu B,Lu HX,Yang H,Liu WC,Li Y

Tue May 20 00:00:00 EDT 2014

Overexpression of FOXM1 predicts poor prognosis and promotes cancer cell proliferation, migration and invasion in epithelial ovarian cancer.

Journal of translational medicine

Wen N,Wang Y,Wen L,Zhao SH,Ai ZH,Wang Y,Wu B,Lu HX,Yang H,Liu WC,Li Y

Tue May 20 00:00:00 EDT 2014

Expression and significance of FOXM1 in human cervical cancer: a tissue micro-array study.

Clinical and investigative medicine. Medecine clinique et experimentale

Guan P,Chen H,Li HJ,Duan J,Chen JY

Tue Feb 01 00:00:00 EST 2011

Bioinformatics

Protein Aliases: FKH L16; FKHL 16; Forkhead box protein M1; forkhead homolog 16; Forkhead like 16; Forkhead, drosophila, homolog-like 16; Forkhead-related protein FKHL16; FOXM 1; FOXM 1c; Hepatocyte nuclear factor 3 forkhead homolog 11; HFH 11; HFH-11; HNF 3; HNF-3/fork-head homolog 11; HNF3; INS 1; INS1; M-phase phosphoprotein 2; MPHOSPH 2; MPM 2; MPM-2 reactive phosphoprotein 2; MPP 2; PIG 29; TGT3; Transcription factor Trident; trident; Winged-helix factor from INS-1 cells; winged-helix transcription factor Trident

Gene Aliases: AA408308; AW554517; BB238854; Fkh16; FKHL16; FOXM1; FOXM1B; HFH-11; HFH-11B; HFH11; HNF-3; INS-1; MPHOSPH2; Mpm2; MPP-2; MPP2; PIG29; TRIDENT; WIN

UniProt ID: (Human) Q08050

Entrez Gene ID: (Human) 2305, (Mouse) 14235

Function(s)

G2/M transition of mitotic cell cycle negative regulation of transcription from RNA polymerase II promoter vasculogenesis liver development DNA repair transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter cellular response to DNA damage stimulus DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator cell cycle positive regulation of cell proliferation anatomical structure morphogenesis negative regulation of stress-activated MAPK cascade regulation of cell proliferation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter regulation of Ras protein signal transduction regulation of cell cycle arrest negative regulation of cell aging regulation of reactive oxygen species metabolic process positive regulation of double-strand break repair response to gonadotropin response to cAMP regulation of cell cycle

Process(es)

RNA polymerase II transcription factor activity, sequence-specific DNA binding protein binding protein kinase binding sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription regulatory region DNA binding

FOXM1 Polyclonal Antibody

Product Details

13147-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

ChIP assay (ChIP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Product Specific Information

Target Information

Bioinformatics

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