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Proteintech
FOXO3A Polyclonal Antibody
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Product Details
10849-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
FOXO3A Fusion Protein Ag1289 (325-673 aa encoded by BC021224)
Conjugate
Form
Liquid
Concentration
0.35 mg/mL
Amount
52.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
The calculated molecular weight of FOXO3 is 71 kDa, but some experiments using a FOXO3a specific antibody showed the expression of a 90 kDa full-length FOXO3a protein (Full) and a 40 kDa processed FOXO3a product (Short).
Immunogen sequence: SPIMASTEL DEVQDDDAPL SPMLYSSSAS LSPSVSKPCT VELPRLTDMA GTMNLNDGLT ENLMDDLLDN ITLPPSQPSP TGGLMQRSSS FPYTTKGSGL GSPTSSFNST VFGPSSLNSL RQSPMQTIQE NKPATFSSMS HYGNQTLQDL LTSDSLSHSD VMMTQSDPLM SQASTAVSAQ NSRRNVMLRN DPMMSFAAQP NQGSLVNQNL LHHQHQTQGA LGGSRALSNS VSNMGLSESS SLGSAKHQQQ SPVSQSMQTL SDSLSGSSLY STSANLPVMG HEKFPSDLDL DMFNGSLECD MESIIRSELM DADGLDFNFD SLISTQNVVG LNVGNFTGAK QASSQSWVPG (325-673 aa encoded by BC021224)
Target Information
USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AF6q21 protein; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO3A-; unnamed protein product
Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; C76856; Fkhr2; FKHRL1; FKHRL1P2; FOXO2; FOXO3; FOXO3A
UniProt ID: (Human) O43524, (Mouse) Q9WVH4
Entrez Gene ID: (Human) 2309, (Mouse) 56484, (Rat) 294515
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase binding
chromatin DNA binding
mitochondrial RNA polymerase binding promoter specificity activity
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
core promoter binding
negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
initiation of primordial ovarian follicle growth
antral ovarian follicle growth
oocyte maturation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of translation
apoptotic process
anatomical structure morphogenesis
cell differentiation
DNA damage response, signal transduction by p53 class mediator
cellular response to oxidative stress
glucose homeostasis
positive regulation of neuron apoptotic process
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neural precursor cell proliferation
regulation of reactive oxygen species metabolic process
transcription from mitochondrial promoter
response to xenobiotic stimulus
positive regulation of autophagy
positive regulation of muscle atrophy
negative regulation of cell migration
response to nutrient levels
tumor necrosis factor-mediated signaling pathway
cellular response to glucose starvation
response to starvation
positive regulation of apoptotic process
positive regulation of regulatory T cell differentiation
negative regulation of neuron differentiation
brain morphogenesis
canonical Wnt signaling pathway
response to fatty acid
cellular response to glucose stimulus
cellular response to corticosterone stimulus
cellular response to hypoxia
response to dexamethasone
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of reactive oxygen species biosynthetic process
cellular response to beta-amyloid
cellular response to nerve growth factor stimulus
response to water-immersion restraint stress
positive regulation of endothelial cell apoptotic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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