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Invitrogen
FOXO3A Polyclonal Antibody
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FIGURE: 1 / 6
FOXO3A Antibody (720128) in ICC/IF
Immunofluorescence was performed on fixed and permeabilized HeLa cells for detection of FOXO3A using Anti-FOXO3A Rabbit Polyclonal Antibody (Product # 720128, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of FOXO3A protein (green), Panel b) is stained for nuclei (blue) using SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). Panel c) represent... View More
Product Details
720128
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Xenopus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide corresponding to Human FOXO3 (aa 29-37)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.1% BSA, 30% glycerol
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
These Polyclonal antibodies are of rabbit origin developed by immunizing animals with proteins or peptides. The polyclonal antibody is purified by affinity purification from the rabbit sera generated after immunizing the rabbits with a specific type of protein or peptide. The purified antibody is tested for its functionality in various relevant research applications. The antibody is developed for Research Use Only and is non-hazardous or non-infectious in nature.
This antibody is predicted to react with Monkey, Goat, Pig, Bovine and Rabbit.
Target Information
USP48 is a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AF6q21 protein; forkhead box O3A; Forkhead box protein O3; forkhead homolog (rhabdomyosarcoma) like 1; Forkhead in rhabdomyosarcoma-like 1; forkhead protein FKHR2; forkhead, Drosophila, homolog of, in rhabdomyosarcoma-like 1; FOXO3A-; unnamed protein product
Gene Aliases: 1110048B16Rik; 2010203A17Rik; AF6q21; C76856; Fkhr2; FKHRL1; FKHRL1P2; FOXO2; FOXO3; FOXO3A
UniProt ID: (Human) O43524, (Mouse) Q9WVH4
Entrez Gene ID: (Human) 2309, (Mouse) 56484
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription cofactor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
beta-catenin binding
protein kinase binding
chromatin DNA binding
mitochondrial RNA polymerase binding promoter specificity activity
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
core promoter binding
negative regulation of transcription from RNA polymerase II promoter
ovulation from ovarian follicle
initiation of primordial ovarian follicle growth
antral ovarian follicle growth
oocyte maturation
transcription, DNA-templated
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
regulation of translation
apoptotic process
anatomical structure morphogenesis
cell differentiation
DNA damage response, signal transduction by p53 class mediator
cellular response to oxidative stress
glucose homeostasis
positive regulation of neuron apoptotic process
positive regulation of erythrocyte differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of canonical Wnt signaling pathway
neuronal stem cell population maintenance
extrinsic apoptotic signaling pathway in absence of ligand
regulation of neural precursor cell proliferation
regulation of reactive oxygen species metabolic process
transcription from mitochondrial promoter
response to xenobiotic stimulus
positive regulation of autophagy
positive regulation of muscle atrophy
negative regulation of cell migration
response to nutrient levels
tumor necrosis factor-mediated signaling pathway
cellular response to glucose starvation
response to starvation
positive regulation of apoptotic process
positive regulation of regulatory T cell differentiation
negative regulation of neuron differentiation
brain morphogenesis
canonical Wnt signaling pathway
response to fatty acid
cellular response to glucose stimulus
cellular response to corticosterone stimulus
cellular response to hypoxia
response to dexamethasone
positive regulation of hydrogen peroxide-mediated programmed cell death
positive regulation of pri-miRNA transcription from RNA polymerase II promoter
positive regulation of reactive oxygen species biosynthetic process
cellular response to beta-amyloid
cellular response to nerve growth factor stimulus
response to water-immersion restraint stress
positive regulation of endothelial cell apoptotic process
Disclaimer
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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